User profiles for M. Artyomov

Maxim Artyomov

Washington University in St.Louis
Verified email at wustl.edu
Cited by 27166

[HTML][HTML] Tumor neoantigens: building a framework for personalized cancer immunotherapy

MM Gubin, MN Artyomov, ER Mardis… - The Journal of …, 2015 - Am Soc Clin Investig
It is now well established that the immune system can recognize developing cancers and
that therapeutic manipulation of immunity can induce tumor regression. The capacity to …

[HTML][HTML] Immune ageing at single-cell resolution

DA Mogilenko, I Shchukina, MN Artyomov - Nature Reviews …, 2022 - nature.com
… and, where possible, we discuss how these findings can be translated to immune system
ageing in humans (the datasets discussed are available to browse through an Artyomov

Itaconate: the poster child of metabolic reprogramming in macrophage function

LAJ O'Neill, MN Artyomov - Nature Reviews Immunology, 2019 - nature.com
Itaconate is one of the best examples of the consequences of metabolic reprogramming
during immunity. It is made by diverting aconitate away from the tricarboxylic acid cycle during …

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

…, CJM Melief, ER Mardis, WE Gillanders, MN Artyomov… - Nature, 2014 - nature.com
The immune system influences the fate of developing cancers by not only functioning as a
tumour promoter that facilitates cellular transformation, promotes tumour growth and sculpts …

[PDF][PDF] Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization

…, B Everts, EJ Pearce, EM Driggers, MN Artyomov - Immunity, 2015 - cell.com
Macrophage polarization involves a coordinated metabolic and transcriptional rewiring that
is only partially understood. By using an integrated high-throughput transcriptional-metabolic …

Fast gene set enrichment analysis

…, V Sukhov, N Budin, B Shpak, MN Artyomov… - BioRxiv, 2016 - biorxiv.org
… Instead of generating nM independent random gene sets: n for each of M input gene sets,
we will generate only n random gene sets of size K. Let π i be an i-th random gene set of size K…

Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas

…, AD Cherniack, G Getz, MN Artyomov… - Nature …, 2016 - nature.com
To compare lung adenocarcinoma (ADC) and lung squamous cell carcinoma (SqCC) and to
identify new drivers of lung carcinogenesis, we examined the exome sequences and copy …

[HTML][HTML] Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation

…, RG Jones, A Diwan, MS Diamond, MN Artyomov - Cell metabolism, 2016 - cell.com
Remodeling of the tricarboxylic acid (TCA) cycle is a metabolic adaptation accompanying
inflammatory macrophage activation. During this process, endogenous metabolites can adopt …

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

…, H Du, NA Abumrad, JF Urban Jr, MN Artyomov… - Nature …, 2014 - nature.com
Alternative (M2) activation of macrophages driven via the α-chain of the receptor for
interleukin 4 (IL-4Rα) is important for immunity to parasites, wound healing, the prevention of …

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

…, J Blagih, GJW Van Der Windt, MN Artyomov… - Nature …, 2014 - nature.com
The ligation of Toll-like receptors (TLRs) leads to rapid activation of dendritic cells (DCs).
However, the metabolic requirements that support this process remain poorly defined. We …