User profiles for M. Artyomov
Maxim ArtyomovWashington University in St.Louis Verified email at wustl.edu Cited by 27166 |
[HTML][HTML] Tumor neoantigens: building a framework for personalized cancer immunotherapy
It is now well established that the immune system can recognize developing cancers and
that therapeutic manipulation of immunity can induce tumor regression. The capacity to …
that therapeutic manipulation of immunity can induce tumor regression. The capacity to …
[HTML][HTML] Immune ageing at single-cell resolution
… and, where possible, we discuss how these findings can be translated to immune system
ageing in humans (the datasets discussed are available to browse through an Artyomov …
ageing in humans (the datasets discussed are available to browse through an Artyomov …
Itaconate: the poster child of metabolic reprogramming in macrophage function
LAJ O'Neill, MN Artyomov - Nature Reviews Immunology, 2019 - nature.com
Itaconate is one of the best examples of the consequences of metabolic reprogramming
during immunity. It is made by diverting aconitate away from the tricarboxylic acid cycle during …
during immunity. It is made by diverting aconitate away from the tricarboxylic acid cycle during …
Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens
The immune system influences the fate of developing cancers by not only functioning as a
tumour promoter that facilitates cellular transformation, promotes tumour growth and sculpts …
tumour promoter that facilitates cellular transformation, promotes tumour growth and sculpts …
[PDF][PDF] Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization
…, B Everts, EJ Pearce, EM Driggers, MN Artyomov - Immunity, 2015 - cell.com
Macrophage polarization involves a coordinated metabolic and transcriptional rewiring that
is only partially understood. By using an integrated high-throughput transcriptional-metabolic …
is only partially understood. By using an integrated high-throughput transcriptional-metabolic …
Fast gene set enrichment analysis
… Instead of generating nM independent random gene sets: n for each of M input gene sets,
we will generate only n random gene sets of size K. Let π i be an i-th random gene set of size K…
we will generate only n random gene sets of size K. Let π i be an i-th random gene set of size K…
Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas
…, AD Cherniack, G Getz, MN Artyomov… - Nature …, 2016 - nature.com
To compare lung adenocarcinoma (ADC) and lung squamous cell carcinoma (SqCC) and to
identify new drivers of lung carcinogenesis, we examined the exome sequences and copy …
identify new drivers of lung carcinogenesis, we examined the exome sequences and copy …
[HTML][HTML] Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation
Remodeling of the tricarboxylic acid (TCA) cycle is a metabolic adaptation accompanying
inflammatory macrophage activation. During this process, endogenous metabolites can adopt …
inflammatory macrophage activation. During this process, endogenous metabolites can adopt …
Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages
Alternative (M2) activation of macrophages driven via the α-chain of the receptor for
interleukin 4 (IL-4Rα) is important for immunity to parasites, wound healing, the prevention of …
interleukin 4 (IL-4Rα) is important for immunity to parasites, wound healing, the prevention of …
TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation
…, J Blagih, GJW Van Der Windt, MN Artyomov… - Nature …, 2014 - nature.com
The ligation of Toll-like receptors (TLRs) leads to rapid activation of dendritic cells (DCs).
However, the metabolic requirements that support this process remain poorly defined. We …
However, the metabolic requirements that support this process remain poorly defined. We …