Retinoblastoma is the most common primary intraocular malignancy of childhood. It typically
presents with leukocoria or strabismus. In later stages of the disease, the child may exhibit …

Glypican 3 (GPC3) is a heparan sulfate proteoglycan and cell surface oncofetal protein which
is highly expressed on a variety of pediatric solid embryonal tumors including the majority …

The COVIDiSTRESS global survey collects data on early human responses to the 2020
COVID-19 pandemic from 173 429 respondents in 48 countries. The open science study was co-…

Modifications of histone proteins have essential roles in normal development and human
disease. Recognition of modified histones by ‘reader’ proteins is a key mechanism that …

… Michael Ortiz has previously served as an expert advisor for Guidepoint Global and has
received research funds from Amgen, none of which is relevant to anything discussed in this …

Viral illnesses remain a significant concern in global health. Rapid and quantitative early
detection of viral oligonucleotides without the need for purification, amplification, or labeling …

Complementary precision cancer medicine paradigms are needed to broaden the clinical
benefit realized through genetic profiling and immunotherapy. In this first-in-class application, …

Purpose: Translocation renal cell carcinoma (tRCC) is a rare, aggressive renal cell
carcinoma (RCC) subtype. There is currently limited understanding on the role of molecular …

SMARCB1 biallelic inactivation resulting in SMARCB1/INI1 deficiency drives a wide range
of malignancies, including many mesenchymal tumors. However, the specific types of …

… Ortiz, MD, 1 Ulrike Gerdemann, MD, 2 Sandya Govinda Raju, MBBS, PhD, 3 Dahlia Henry,
BA, 3 Steve Smith, BS, 4 S. Michael Rothenberg, MD, PhD, 3 Michael C. Cox, MHS, BCOP …