Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by extensive synovitis
resulting in erosions of articular cartilage and marginal bone that lead to joint destruction…

The complement system is a component of the innate immune system. Its main function was
initially believed to be limited to the recognition and elimination of pathogens through direct …

Rheumatoid Arthritis (RA) is a chronic inflammatory disease characterized by a heterogeneous
clinical response to the different treatments. Some patients are difficult to treat and do not …

Objective Early diagnosis of spondyloarthritis (SpA) is sometimes difficult owing to the lack
of reliable diagnostic criteria. The objective of this study was to determine the diagnostic …

Rheumatoid arthritis (RA) is a systemic chronic inflammatory disease characterized by
extensive synovitis resulting in erosions of articular cartilage and marginal bone with joint …

Autoimmune rheumatic diseases are characterised by an abnormal immune system response,
complement activation, cytokines dysregulation and inflammation. In last years, despite …

… discovered through single-cell sequencing in an Alzheimer’s disease mouse model, DAM
were subsequently identified in amyotrophic lateral sclerosis, aging, and multiple sclerosis …

The relationship between the complement system and autoimmunity appears paradoxical as
both the deficiency and the activation contribute to inducing autoimmune diseases. In these …

… infections), rashes, elevated transaminase levels, worsening or initiation of congestive
heart failure, lupus-like syndrome, lymphomas, and worsening or initiation of multiple sclerosis …

The complement system is an essential component of innate immunity and also plays an
important role in modulating adaptive immunity. It comprises more than 30 plasma and …