User profiles for M. R. Leroux

Michel Leroux

Simon Fraser University
Verified email at sfu.ca
Cited by 15275

Genes and molecular pathways underpinning ciliopathies

JF Reiter, MR Leroux - Nature reviews Molecular cell biology, 2017 - nature.com
Motile and non-motile (primary) cilia are nearly ubiquitous cellular organelles. The dysfunction
of cilia causes diseases known as ciliopathies. The number of reported ciliopathies (…

The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization

JF Reiter, OE Blacque, MR Leroux - EMBO reports, 2012 - embopress.org
Both the basal body and the microtubule‐based axoneme it nucleates have evolutionarily
conserved subdomains crucial for cilium biogenesis, function and maintenance. Here, we …

[HTML][HTML] The sensory cilia of Caenorhabditis elegans.

PN Inglis, G Ou, MR Leroux, JM Scholey - WormBook, 2007 - ncbi.nlm.nih.gov
The non-motile cilium, once believed to be a vestigial cellular structure, is now increasingly
associated with the ability of a wide variety of cells and organisms to sense their chemical …

[HTML][HTML] Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene

…, RA Lewis, JS Green, PS Parfrey, MR Leroux… - Cell, 2004 - cell.com
Cilia and flagella are microtubule-based structures nucleated by modified centrioles termed
basal bodies. These biochemically complex organelles have more than 250 and 150 …

Basal body dysfunction is a likely cause of pleiotropic Bardet–Biedl syndrome

…, RC Johnsen, JC Cavender, R Alan Lewis, MR Leroux… - Nature, 2003 - nature.com
Bardet–Biedl syndrome (BBS) is a genetically heterogeneous disorder characterized primarily
by retinal dystrophy, obesity, polydactyly, renal malformations and learning disabilities. …

The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4

…, D Goldman, P Nurnberg, A Swaroop, MR Leroux… - Nature …, 2006 - nature.com
The molecular basis of nephronophthisis 1 , the most frequent genetic cause of renal failure
in children and young adults, and its association with retinal degeneration and cerebellar …

Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates

…, PM Munro, S Fisher, PL Tan, HM Phillips, MR Leroux… - Nature …, 2005 - nature.com
The evolutionarily conserved planar cell polarity (PCP) pathway (or noncanonical Wnt
pathway) drives several important cellular processes, including epithelial cell polarization, cell …

MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis

…, N Chen, OE Blacque, BK Yoder, MR Leroux - Journal of Cell …, 2011 - rupress.org
Leroux; MKS and NPHP modules cooperate to establish basal body/transition zone membrane
associations and ciliary gate function during ciliogenesis. J Cell Biol 21 March 2011; 192 …

Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport

…, LM Quarmby, SR Wicks, MR Leroux - Genes & …, 2004 - genesdev.cshlp.org
Bardet-Biedl syndrome (BBS) is a genetically heterogeneous developmental disorder whose
molecular basis is largely unknown. Here, we show that mutations in the Caenorhabditis …

Functional coordination of intraflagellar transport motors

G Ou, O E. Blacque, JJ Snow, MR Leroux, JM Scholey - Nature, 2005 - nature.com
Cilia have diverse roles in motility and sensory reception, and defects in cilia function
contribute to ciliary diseases such as Bardet–Biedl syndrome (BBS). Intraflagellar transport (IFT) …