User profiles for M. R. Koelle
Michael R. KoelleAssociate Professor of Molecular Biophysics & Biochemistry, Yale University Verified email at yale.edu Cited by 5497 |
[HTML][HTML] Biogenic amine neurotransmitters in C. elegans
DL Chase, MR Koelle - WormBook: The Online Review of C …, 2007 - ncbi.nlm.nih.gov
Four biogenic amines: octopamine, tyramine, dopamine and serotonin act in C. elegans to
modulate behavior in response to changing environmental cues. These neurotransmitters act …
modulate behavior in response to changing environmental cues. These neurotransmitters act …
A new family of G-protein regulators—the RGS proteins
MR Koelle - Current opinion in cell biology, 1997 - Elsevier
… of G-protein regulators - the RGS proteins Michael R Koelle … of G-protein regulators - the
RGS proteins Michael R Koelle … family of G-protein regulators - the RGS proteins Koelle 145 …
RGS proteins Michael R Koelle … family of G-protein regulators - the RGS proteins Koelle 145 …
The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily
MR Koelle, WS Talbot, WA Segraves, MT Bender… - Cell, 1991 - cell.com
The steroid hormone ecdysone triggers coordinate changes in Drosophila tissue development
that result in metamorphosis. To advance our understanding of the genetic regulatory …
that result in metamorphosis. To advance our understanding of the genetic regulatory …
[HTML][HTML] EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins
MR Koelle, HR Horvitz - Cell, 1996 - cell.com
The frequencies of certain periodic behaviors of the nematode C. elegans are regulated in a
dose-dependent manner by the activity of the gene egl-10. These behaviors are modulated …
dose-dependent manner by the activity of the gene egl-10. These behaviors are modulated …
[HTML][HTML] Neurotransmitter signaling through heterotrimeric G proteins: insights from studies in C. elegans
MR Koelle - WormBook: The Online Review of C. elegans Biology …, 2018 - ncbi.nlm.nih.gov
Neurotransmitters signal via G protein coupled receptors (GPCRs) to modulate activity of
neurons and muscles. C. elegans has∼ 150 G protein coupled neuropeptide receptor …
neurons and muscles. C. elegans has∼ 150 G protein coupled neuropeptide receptor …
Mechanism of extrasynaptic dopamine signaling in Caenorhabditis elegans
DL Chase, JS Pepper, MR Koelle - Nature neuroscience, 2004 - nature.com
D1-like and D2-like dopamine receptors have synergistic and antagonistic effects on behavior.
To understand the mechanisms underlying these effects, we studied dopamine signaling …
To understand the mechanisms underlying these effects, we studied dopamine signaling …
Genetic and cellular basis for acetylcholine inhibition of Caenorhabditis elegans egg-laying behavior
Egg-laying behavior in Caenorhabditis elegans is activated by signaling through the G-protein
Gρ q and inhibited by signaling through a second G-protein, Gρ o . Activation of egg …
Gρ q and inhibited by signaling through a second G-protein, Gρ o . Activation of egg …
Antagonism between Goα and Gqα in Caenorhabditis elegans: the RGS protein EAT-16 is necessary for Goα signaling and regulates Gqα activity
…, WJ Chen, G Patikoglou, MR Koelle… - Genes & …, 1999 - genesdev.cshlp.org
To elucidate the cellular role of the heterotrimeric G protein G o , we have taken a molecular
genetic approach inCaenorhabditis elegans. We screened for suppressors of activated GOA-…
genetic approach inCaenorhabditis elegans. We screened for suppressors of activated GOA-…
[PDF][PDF] Neural architecture of hunger-dependent multisensory decision making in C. elegans
Little is known about how animals integrate multiple sensory inputs in natural environments
to balance avoidance of danger with approach to things of value. Furthermore, the …
to balance avoidance of danger with approach to things of value. Furthermore, the …
Activity of the C. elegans egg-laying behavior circuit is controlled by competing activation and feedback inhibition
10.7554/eLife.21126.001 Like many behaviors, Caenorhabditis elegans egg laying alternates
between inactive and active states. To understand how the underlying neural circuit turns …
between inactive and active states. To understand how the underlying neural circuit turns …