User profiles for M. N. Wass
Mark N WassProfessor of Computational Biology, University of Kent Verified email at kent.ac.uk Cited by 16680 |
The Phyre2 web portal for protein modeling, prediction and analysis
… In the past, the sequence database was mined using programs such as Position-Specific
Iterated Basic Local Alignment Search Tool (PSI-BLAST) 14 that iteratively evolve a profile …
Iterated Basic Local Alignment Search Tool (PSI-BLAST) 14 that iteratively evolve a profile …
The flagellum in malarial parasites
… history of malarial research, it was the lashing of the parasite's … flagella was indeed a living
organism, and was responsible … Neither hypothesis was correct, the crescents are the linear …
organism, and was responsible … Neither hypothesis was correct, the crescents are the linear …
[HTML][HTML] A large-scale evaluation of computational protein function prediction
… was ineluctably biased owing to experimenter and annotator choice during the evaluation
time frame. Thus, the set of targets was first analyzed to establish that it was … targets was …
time frame. Thus, the set of targets was first analyzed to establish that it was … targets was …
3DLigandSite: predicting ligand-binding sites using similar structures
… The FINDSITE data set was filtered using our list of accepted … 3DLigandSite performance
was assessed using a range of … This setting was selected for use in the 3DLigandSite server …
was assessed using a range of … This setting was selected for use in the 3DLigandSite server …
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
… We considered the gene containing the nsSNP to be a strong candidate when (i) the
nsSNP and the sentinel SNPs were in LD (r 2 > 0.5) and (ii) there was no evidence for …
nsSNP and the sentinel SNPs were in LD (r 2 > 0.5) and (ii) there was no evidence for …
Challenges for the prediction of macromolecular interactions
MN Wass, A David, MJE Sternberg - Current opinion in structural biology, 2011 - Elsevier
… Accordingly, here we report the key findings of our analysis (David A, Wass MN, Sternberg
… aligned and the number of distinct binding sites was identified. We found that ligand binding …
… aligned and the number of distinct binding sites was identified. We found that ligand binding …
[HTML][HTML] The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens
… was held) and in 2017 (when CAFA3 was held), which suggests little change in term
frequencies in the annotation database since 2014. In MFO, the BLAST method based on the …
frequencies in the annotation database since 2014. In MFO, the BLAST method based on the …
[HTML][HTML] An expanded evaluation of protein function prediction methods shows an improvement in accuracy
… predictions were submitted and was used to estimate the performance accuracy. The
estimated performance was subsequently used to draw conclusions about the status of the field. …
estimated performance was subsequently used to draw conclusions about the status of the field. …
Genetic variation in SCN10A influences cardiac conduction
…, S Parasramka, I El-Hamamsy, MN Wass… - Nature …, 2010 - nature.com
To identify genetic factors influencing cardiac conduction, we carried out a genome-wide
association study of electrocardiographic time intervals in 6,543 Indian Asians. We identified …
association study of electrocardiographic time intervals in 6,543 Indian Asians. We identified …
[HTML][HTML] Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant of SARS-CoV-2 isolates
… This work was supported by the Frankfurter Stiftung für krebskranke Kinder. The authors
thank Lena Stegmann, Kerstin Euler and Sebastian Grothe for their technical assistance. …
thank Lena Stegmann, Kerstin Euler and Sebastian Grothe for their technical assistance. …