User profiles for M. N. Wass

Mark N Wass

Professor of Computational Biology, University of Kent
Verified email at kent.ac.uk
Cited by 16680

The Phyre2 web portal for protein modeling, prediction and analysis

LA Kelley, S Mezulis, CM Yates, MN Wass… - Nature protocols, 2015 - nature.com
… In the past, the sequence database was mined using programs such as Position-Specific
Iterated Basic Local Alignment Search Tool (PSI-BLAST) 14 that iteratively evolve a profile …

The flagellum in malarial parasites

RE Sinden, A Talman, SR Marques, MN Wass… - Current opinion in …, 2010 - Elsevier
… history of malarial research, it was the lashing of the parasite's … flagella was indeed a living
organism, and was responsible … Neither hypothesis was correct, the crescents are the linear …

[HTML][HTML] A large-scale evaluation of computational protein function prediction

…, H Shatkay, F Gatzmann, I Sommer, MN Wass… - Nature …, 2013 - nature.com
was ineluctably biased owing to experimenter and annotator choice during the evaluation
time frame. Thus, the set of targets was first analyzed to establish that it was … targets was

3DLigandSite: predicting ligand-binding sites using similar structures

MN Wass, LA Kelley, MJE Sternberg - Nucleic acids research, 2010 - academic.oup.com
… The FINDSITE data set was filtered using our list of accepted … 3DLigandSite performance
was assessed using a range of … This setting was selected for use in the 3DLigandSite server …

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

JC Chambers, W Zhang, J Sehmi, X Li, MN Wass… - Nature …, 2011 - nature.com
… We considered the gene containing the nsSNP to be a strong candidate when (i) the
nsSNP and the sentinel SNPs were in LD (r 2 > 0.5) and (ii) there was no evidence for …

Challenges for the prediction of macromolecular interactions

MN Wass, A David, MJE Sternberg - Current opinion in structural biology, 2011 - Elsevier
… Accordingly, here we report the key findings of our analysis (David A, Wass MN, Sternberg
… aligned and the number of distinct binding sites was identified. We found that ligand binding …

[HTML][HTML] The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens

…, J Gough, AA Freitas, M Antczak, F Fabris, MN Wass… - Genome biology, 2019 - Springer
was held) and in 2017 (when CAFA3 was held), which suggests little change in term
frequencies in the annotation database since 2014. In MFO, the BLAST method based on the …

[HTML][HTML] An expanded evaluation of protein function prediction methods shows an improvement in accuracy

…, S Vucetic, Z Wang, MJE Sternberg, MN Wass… - Genome biology, 2016 - Springer
… predictions were submitted and was used to estimate the performance accuracy. The
estimated performance was subsequently used to draw conclusions about the status of the field. …

Genetic variation in SCN10A influences cardiac conduction

…, S Parasramka, I El-Hamamsy, MN Wass… - Nature …, 2010 - nature.com
To identify genetic factors influencing cardiac conduction, we carried out a genome-wide
association study of electrocardiographic time intervals in 6,543 Indian Asians. We identified …

[HTML][HTML] Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant of SARS-CoV-2 isolates

D Bojkova, M Widera, S Ciesek, MN Wass, M Michaelis… - Cell research, 2022 - nature.com
… This work was supported by the Frankfurter Stiftung für krebskranke Kinder. The authors
thank Lena Stegmann, Kerstin Euler and Sebastian Grothe for their technical assistance. …