Given sufficient large protein families, and using a global statistical inference approach, it is
possible to obtain sufficient accuracy in protein residue contact predictions to predict the …

Of the more than 190 distinct species of Mycobacterium genus, many are economically and
clinically important pathogens of humans or animals. Among those mycobacteria that infect …

Recent advances in the scale and diversity of population genomic datasets for bacteria now
provide the potential for genome-wide patterns of co-evolution to be studied at the resolution …

Motivation: Recently it has been shown that the quality of protein contact prediction from
evolutionary information can be improved significantly if direct and indirect information is …

The controlled assembly of replication forks is critical for genome stability. The Dbf4-dependent
Cdc7 kinase (DDK) initiates replisome assembly by phosphorylating the MCM2-7 …

Recently, several new contact prediction methods have been published. They use (i) large
sets of multiple aligned sequences and (ii) assume that correlations between columns in …

Correlation patterns in multiple sequence alignments of homologous proteins can be
exploited to infer information on the three-dimensional structure of their members. The typical …

Proteins are the" building blocks of life", the most abundant organic molecules, and the central
focus of most areas of biomedicine. Protein structure is strongly related to protein function, …

Abstract Model Quality Assessment Programs (MQAPs) are programs developed to rank
protein models. These methods can be trained to predict the overall global quality of a model or …

Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase that binds to and is
activated by collagens. DDR1 expression increases following kidney injury and accumulating …