Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms

…, BD Snarr, N Alnabelseya, MJ Pestrak, MJ Lee… - Science …, 2016 - science.org
Bacterial biofilms present a significant medical challenge because they are recalcitrant to
current therapeutic regimes. A key component of biofilm formation in the opportunistic human …

[HTML][HTML] Pseudomonas aeruginosa rugose small-colony variants evade host clearance, are hyper-inflammatory, and persist in multiple host environments

MJ Pestrak, SB Chaney, HC Eggleston… - PLoS …, 2018 - journals.plos.org
Pseudomonas aeruginosa causes devastating infections in immunocompromised individuals.
Once established, P. aeruginosa infections become incredibly difficult to treat due to the …

Treatment with the Pseudomonas aeruginosa glycoside hydrolase PslG combats wound infection by improving antibiotic efficacy and host innate immune activity

MJ Pestrak, P Baker, S Dellos-Nolan… - Antimicrobial agents …, 2019 - Am Soc Microbiol
Pseudomonas aeruginosa is an opportunistic, nosocomial bacterial pathogen that forms
persistent infections due to the formation of protective communities, known as biofilms. Once the …

[HTML][HTML] Characterization of the Pseudomonas aeruginosa glycoside hydrolase PslG reveals that its levels are critical for Psl polysaccharide biosynthesis and biofilm …

…, GB Whitfield, PJ Hill, DJ Little, MJ Pestrak… - Journal of Biological …, 2015 - ASBMB
A key component of colonization, biofilm formation, and protection of the opportunistic human
pathogen Pseudomonas aeruginosa is the biosynthesis of the exopolysaccharide Psl. …

[HTML][HTML] Investigation of synovial fluid induced Staphylococcus aureus aggregate development and its impact on surface attachment and biofilm formation

MJ Pestrak, TT Gupta, DH Dusane, DV Guzior… - PLoS …, 2020 - journals.plos.org
Periprosthetic joint infections (PJIs) are a devastating complication that occurs in 2% of
patients following joint replacement. These infections are costly and difficult to treat, often …

Staphylococcus aureus aggregates on orthopedic materials under varying levels of shear stress

TT Gupta, NK Gupta, MJ Pestrak… - Applied and …, 2020 - Am Soc Microbiol
Periprosthetic joint infection (PJI) occurring after artificial joint replacement is a major clinical
issue requiring multiple surgeries and antibiotic interventions. Staphylococcus aureus is the …

[HTML][HTML] Pseudomonas aeruginosa pulmonary infection results in S100A8/A9-dependent cardiac dysfunction

N Kumar, MJ Pestrak, Q Wu, OS Ahumada… - PLoS …, 2023 - journals.plos.org
Pseudomonas aeruginosa (P.a.) infection accounts for nearly 20% of all cases of hospital
acquired pneumonia with mortality rates >30%. P.a. infection induces a robust inflammatory …

Regulation of Cyclic di-GMP Signaling in Pseudomonas aeruginosa

MJ Pestrak, DJ Wozniak - Microbial Cyclic Di-Nucleotide Signaling, 2020 - Springer
Pseudomonas aeruginosa is found ubiquitously throughout the environment, and it readily
adapts to survive in different environments. Genome analysis reveals P. aeruginosa has a …

Genetics and regulation of EPS formation in Pseudomonas aeruginosa

MJ Pestrak, HC Eggleston… - The Perfect Slime …, 2016 - books.google.com
The Gram-negative opportunistic pathogen Pseudomonas aeruginosa is of increasing clinical
importance due to its involvement in a variety of acute and chronic infections. One of the …

Correction: Investigation of synovial fluid induced Staphylococcus aureus aggregate development and its impact on surface attachment and biofilm formation

MJ Pestrak, TT Gupta, DH Dusane, DV Guzior, A Staats… - Plos one, 2020 - journals.plos.org
… Copyright: © 2020 Pestrak et al. This is an open access article distributed under the terms
of the Creative Commons Attribution License, which permits unrestricted use, distribution, and …