Development of safe and effective COVID-19 vaccines is a global priority and the best hope
for ending the COVID-19 pandemic. Remarkably, in less than 1 year, vaccines have been …

Epigenetic proteins are intently pursued targets in ligand discovery. So far, successful efforts
have been limited to chromatin modifying enzymes, or so-called epigenetic ‘writers’ and ‘…

Progressive immune-associated injury is a hallmark of severe acute respiratory syndrome (SARS).
Viral evasion of innate immunity, hypercytokinemia and systemic immunopathology in …

Correlates of immune-mediated protection to most viral and cancer vaccines are still unknown.
This impedes the development of novel vaccines to incurable diseases such as HIV and …

<p>Human immunodeficiency virus (HIV) persistence in latently infected resting memory
CD4+ T-cells is the major barrier to HIV cure. Cellular histone deacetylases (HDACs) are …

An unusual group of carcinomas, here termed nuclear protein in testis (NUT) midline
carcinomas (NMC), are characterized by translocations that involve NUT, a novel gene on …

The immune system is skilled in communication and designed to respond quickly, specifically
and globally to protect an organism against foreign invaders and disease. The cytokine …

It is not understood how immune inflammation influences the pathogenesis of severe acute
respiratory syndrome (SARS). One area of strong controversy is the role of interferon (IFN) …

How viral and host factors contribute to the severe pathogenicity of the H5N1 subtype of
avian influenza virus infection in humans is poorly understood. We identified three clusters of …

NUT midline carcinoma (NMC) is a uniformly lethal malignancy that is defined by
rearrangement of the nuclear protein in testis (NUT) gene on chromosome 15q14. NMCs are …