Background: Closed suction systems (CSS) are increasingly replacing open suction systems
(OSS) to perform endotracheal toilet in mechanically ventilated intensive care unit patients. …

The burden of community-acquired pneumonia (CAP) among the elderly is high and has
increased over the last decades. Streptococcus pneumoniae is the most common cause of CAP …

Introduction Coronavirus disease (COVID‐19) is associated with a high incidence of thrombosis
and mortality despite standard anticoagulant thromboprophylaxis. There is equipoise …

The acute phase of sepsis is characterized by a strong inflammatory reaction. At later stages
in some patients, immunoparalysis may be encountered, which is associated with a poor …

Background Host responses during sepsis are highly heterogeneous, which hampers the
identification of patients at high risk of mortality and their selection for targeted therapies. In this …

Preclinical studies have suggested that platelets influence the host response during sepsis.
We sought to assess the association of admission thrombocytopenia with the presentation, …

Introduction A clinical suspicion of infection is mandatory for diagnosing sepsis in patients
with a systemic inflammatory response syndrome. Yet, the accuracy of categorizing critically ill …

The high prevalence of nosocomial infections in critically ill ICU patients is associated with
high antibiotic consumption. Besides its economic impact, there is the constant threat of …

Rationale: Patients admitted to intensive care units with sepsis are prone to developing
cardiac dysrhythmias, most commonly atrial fibrillation. Objectives: To determine the incidence, …

Risk factors for the development of ventilator-associated pneumonia (VAP) and colonization
of the respiratory tract and stomach with enteric gram-negative bacteria (EGB) and …