During embryogenesis, precise gene transcription in space and time requires that distal
enhancers and promoters communicate by physical proximity within gene regulatory landscapes…

In the past 15 years our perception of nuclear envelope function has evolved perhaps
nearly as much as the nuclear envelope itself evolved in the last 3 billion years. Historically …

It is well established that the nuclear envelope has many distinct direct connections to
chromatin that contribute to genome organization. The functional consequences of genome …

MYCN amplification drives one in six cases of neuroblastoma. The supernumerary gene
copies are commonly found on highly rearranged, extrachromosomal circular DNA (ecDNA). …

Whether gene repositioning to the nuclear periphery during differentiation adds another
layer of regulation to gene expression remains controversial. Here, we resolve this by …

Long non-coding RNAs (lncRNAs) can be important components in gene-regulatory networks
1 , but the exact nature and extent of their involvement in human Mendelian disease is …

While analyzing the DNA methylome of multiple myeloma (MM), a plasma cell neoplasm, by
whole-genome bisulfite sequencing and high-density arrays, we observed a highly …

Regulatory landscapes drive complex developmental gene expression, but it remains unclear
how their integrity is maintained when incorporating novel genes and functions during …

The 3D organization of the genome changes concomitantly with expression changes during
hematopoiesis and immune activation. Studies have focused either on lamina-associated …

Human genome-wide association studies have linked single-nucleotide polymorphisms (SNPs)
in NEMP1 (nuclear envelope membrane protein 1) with early menopause; however, it is …