An ever-increasing demand for novel antimicrobials to treat life-threatening infections caused
by the global spread of multidrug-resistant bacterial pathogens stands in stark contrast to …

Starting with the earliest Streptomyces genome sequences, the promise of natural product
genome mining has been captivating: genomics and bioinformatics would transform …

Actinobacteria constitute a highly diverse bacterial phylum with an unrivalled metabolic
versatility. They produce most of the clinically used antibiotics and a plethora of other natural …

Many microorganisms produce natural products that form the basis of antimicrobials,
antivirals, and other drugs. Genome mining is routinely used to complement screening-based …

Secondary metabolites produced by bacteria and fungi are an important source of
antimicrobials and other bioactive compounds. In recent years, genome mining has seen broad …

Microbial secondary metabolism constitutes a rich source of antibiotics, chemotherapeutics,
insecticides and other high-value chemicals. Genome mining of gene clusters that encode …

Microorganisms produce small bioactive compounds as part of their secondary or specialised
metabolism. Often, such metabolites have antimicrobial, anticancer, antifungal, antiviral or …

Bacterial and fungal secondary metabolism is a rich source of novel bioactive compounds
with potential pharmaceutical applications as antibiotics, anti-tumor drugs or cholesterol-…

… Medema, antiSMASH 4.0—improvements in chemistry prediction and gene cluster boundary
identification, Nucleic Acids Research, Volume 45, Issue W1, 3 July 2017, Pages W36–W41…

Soils harbour some of the most diverse microbiomes on Earth and are essential for both
nutrient cycling and carbon storage. To understand soil functioning, it is necessary to model the …