… The two most active phenazines in vitro were either inactive (3a) or had a borderline activity
(6a) in vivo at the doses of 200 mg/kg by oral route. Given by subcutaneous route 3a was …

Background Malaria was eliminated from southern and southeastern Brazil over 50 years
ago. However, an increasing number of autochthonous episodes attributed to Plasmodium …

… MG-Brazil, given to mice inoculated with P. berghei blood parasites, reduced parasitaemia
up to 60% at doses of 250 and 500 mg/kg; however, at a dose of 1000 mg/… mg/kg; 4000 mg/kg …

… extraction, cultivated parasites were centrifuged and suspended in NET buffer (150 mM
NaCl, 10 mM EDTA, 50 mM Tris, pH 7.5) and treated with 1% sarcosyl and proteinase K (20 mg/…

… berghei-infected mice at a dose of 100 mg/kg at least until day 21 postinfection. Treatment
with BAA in doses of 10 and 50 mg/kg, however, did not affect the mortality rate of P. berghei-…

Background In Brazil, two species of Plasmodium have been described infecting non-human
primates, Plasmodium brasilianum and Plasmodium simium. These species are …

Amodiaquine (AQ) is currently being used as a partner drug in combination with artesunate
for treatment of uncomplicated malaria in most endemic countries of Africa. In the absence of …

The widespread occurrence of drug-resistant malaria parasites in South America presents a
formidable obstacle to disease control in this region. To characterize parasite populations …

Zoonotic malaria poses a unique problem for malaria control. Autochthonous cases of
human malaria in the Atlantic Forest have recently been attributed to Plasmodium simium, a …

In Brazil, no study has been done concerning the detection of malaria parasites by polymerase
chain reaction (PCR) related to the diagnosis of Plasmodium falciparum malaria. In the …