User profiles for M. E. Wall

Michael E. Wall

Research Scientist, Los Alamos National Laboratory
Verified email at lanl.gov
Cited by 4599

Camptothecin and taxol: discovery to clinic—thirteenth Bruce F. Cain Memorial Award Lecture

ME Wall, MC Wani - Cancer research, 1995 - AACR
… During the period 1950—1959,ME Wall was the director of … Wall becameintenselyinterestedin
discoveringthe natureof the … MC Wani joined Wall's group commencing a fruitful 30-year …

Camptothecin and taxol: discovery to clinic

ME Wall - Medicinal research reviews, 1998 - Wiley Online Library
… By 1963 a sizable sample of approximately 20 kg of the wood and bark of the tree became
available to me, and in 1964 Dr. MC Wani joined my group, commencing a fruitful 30-year …

Design of gene circuits: lessons from bacteria

ME Wall, WS Hlavacek, MA Savageau - Nature Reviews Genetics, 2004 - nature.com
Researchers are now building synthetic circuits for controlling gene expression and considering
practical applications for engineered gene circuits. What can we learn from nature about …

Plant antitumor agents. VI. Isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia

MC Wani, HL Taylor, ME Wall, P Coggon… - Journal of the …, 1971 - ACS Publications
OC——Br antileukemic and tumor inhibitory properties6 and is the first compound possessing
the taxane6 ring which has been demonstrated to have such activity. The alcohol extract …

Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata1,2

ME Wall, MC Wani, CE Cook, KH Palmer… - Journal of the …, 1966 - ACS Publications
Ethyl glycinate 78 66 38 14 Methyl DL-alaninate 52 32 11 0 Methyl a-aminoisobutyrate 0 0
0 0 is allowed to react with equimolar solutions of various amino acids esters in a number of …

Singular value decomposition and principal component analysis

ME Wall, A Rechtsteiner, LM Rocha - A practical approach to microarray …, 2003 - Springer
One of the challenges of bioinformatics is to develop effective ways to analyze global gene
expression data. A rigorous approach to gene expression analysis must involve an up-front …

Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis

…, AD Kinghorn, DM Brown, MC Wani, ME Wall… - Nature medicine, 1995 - nature.com
As a result of bioassay–guided fractionation, betulinic acid, a pentacyclic triterpene, was
identified as a melanoma–specific cytotoxic agent. In follow–up studies conducted with athymic …

Germination of Witchweed (Striga lutea Lour.): Isolation and Properties of a Potent Stimulant

CE Cook, LP Whichard, B Turner, ME Wall, GH Egley - Science, 1966 - science.org
A crystalline germination stimulant (trivial name strigol) for the root parasite, witchweed (Striga
lutea Lour.), has been isolated from cotton root exudates and characterized as a C 19 H …

DNA topoisomerase I—targeted chemotherapy of human colon cancer in xenografts

BC Giovanella, JS Stehlin, ME Wall, MC Wani… - Science, 1989 - science.org
… The disease was evaluated at (i) an early stage, with tumors confined to the primary site
and with various depth of colonic wall penetration (stages B1 to B3, modified Duke's …

Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor …

C Jaxel, KW Kohn, MC Wani, ME Wall, Y Pommier - Cancer research, 1989 - AACR
… All gels were run at 1.4 V/cm for 15 h and contained 2 Me/ml chloroquine in order to
separate nicked, relaxed, and supercoiled DNA molecules. Negatives of the gel pictures were …