User profiles for M. D. Schaffler

Melanie Schaffler

PhD candidate, University of Pennsylvania
Verified email at pennmedicine.upenn.edu
Cited by 457

[HTML][HTML] Mechanisms of tactile sensory phenotypes in autism: current understanding and future directions for research

MD Schaffler, LJ Middleton, I Abdus-Saboor - Current Psychiatry Reports, 2019 - Springer
Purpose of Review This review aims to summarize the current body of behavioral, physiological,
and molecular knowledge concerning tactile sensitivity in autism spectrum disorder (…

Germline Chd8 haploinsufficiency alters brain development in mouse

…, TW Stradleigh, MC Pride, MD Schaffler… - Nature …, 2017 - nature.com
The chromatin remodeling gene CHD8 represents a central node in neurodevelopmental
gene networks implicated in autism. We examined the impact of germline heterozygous …

[PDF][PDF] Touch neurons underlying dopaminergic pleasurable touch and sexual receptivity

LJ Elias, IK Succi, MD Schaffler, W Foster, MA Gradwell… - Cell, 2023 - cell.com
Pleasurable touch is paramount during social behavior, including sexual encounters.
However, the identity and precise role of sensory neurons that transduce sexual touch remain …

[HTML][HTML] R-baclofen reverses cognitive deficits and improves social interactions in two lines of 16p11. 2 deletion mice

LJ Stoppel, TM Kazdoba, MD Schaffler… - …, 2018 - nature.com
Human chromosome 16p11. 2 microdeletion is among the most common gene copy number
variations (CNVs) known to confer risk for intellectual disability (ID) and autism spectrum …

Touchscreen learning deficits and normal social approach behavior in the Shank3B model of Phelan–McDermid syndrome and autism

NA Copping, EL Berg, GM Foley, MD Schaffler… - Neuroscience, 2017 - Elsevier
SHANK3 is a synaptic scaffolding protein localized in the postsynaptic density and has a
crucial role in synaptogenesis and neural physiology. Deletions and point mutations in …

[HTML][HTML] Towards Preclinical Validation of Arbaclofen (R-baclofen) Treatment for 16p11. 2 Deletion Syndrome

BB Gundersen, WT O'Brien, MD Schaffler, MN Schultz… - bioRxiv, 2023 - ncbi.nlm.nih.gov
A microdeletion on human chromosome 16p11. 2 is one of the most common copy number
variants associated with autism spectrum disorder and other neurodevelopmental disabilities…

A critical role for touch neurons in a skin-brain pathway for stress resilience

MD Schaffler, M Johnson, B Hing, P Kahler, I Hultman… - bioRxiv, 2022 - biorxiv.org
Social touch can act as a stress buffer, reducing behavioral and physiological responses to
stressful scenarios. However, skin-brain touch pathways that promote stress resilience …

Heterozygous mutation to Chd8 causes macrocephaly and widespread alteration of neurodevelopmental transcriptional networks in mouse

…, I Zdilar, NA Copping, MC Pride, MD Schaffler… - bioRxiv, 2016 - biorxiv.org
The chromatin remodeling gene CHD8 represents a central node in early neurodevelopmental
gene networks implicated in autism. We examined the impact of heterozygous germline …

C1q/TNF-related protein-3 represents a novel and endogenous lipopolysaccharide antagonist of the adipose tissue

…, M Neumeier, J Scholmerich, A Schaffler - …, 2010 - academic.oup.com
… By using a designed TLR4/MD-2 fusion molecule, it is shown by different techniques that
CTRP-3 specifically and effectively inhibits the binding of LPS to its receptor, TLR4/MD-2. CTRP…

Fatty acids as metabolic mediators in innate immunity

…, M Neumeier, J Schölmerich, A Schäffler - European journal of …, 2009 - Wiley Online Library
… -based (biotin-streptavidin-peroxidase) TLR4/MD-2 assay that was developed by our group
… (Table 2) did not influence the binding of biotinylated LPS to TLR4/MD-2 (data not shown). …