Polymeric nanoparticles (NPs) are a promising platform for medical applications in drug
delivery. However, their use as drug carriers is limited by biological (eg, immunological) barriers …

Prader-Willi syndrome (PWS) is an imprinted neurodevelopmental disease caused by a loss
of paternal genes on chromosome 15q11-q13. It is characterized by cognitive impairments, …

Autism spectrum disorder (ASD) is diagnosed by two core behavioral criteria, unusual
reciprocal social interactions and communication, and stereotyped, repetitive behaviors with …

The chromatin remodeling gene CHD8 represents a central node in neurodevelopmental
gene networks implicated in autism. We examined the impact of germline heterozygous …

Stressful life experiences are known to be a precipitating factor for many mental disorders.
The social defeat model induces behavioral responses in rodents (eg reduced social …

Background Autism spectrum disorder (ASD) is a clinically and biologically heterogeneous
condition characterized by social, repetitive, and sensory behavioral abnormalities. No …

Oxytocin (OT) is a neuropeptide involved in mammalian social behavior. It is currently in
clinical trials for the treatment of autism spectrum disorder (ASD). Previous studies in healthy …

Mutations in the SHANK3 gene have been discovered in autism spectrum disorder (ASD),
and the intellectual disability, Phelan‐McDermid Syndrome. This study leveraged a new rat …

Maternally derived copy number gains of human chromosome 15q11.2-q13.3 (Dup15q
syndrome or Dup15q) cause intellectual disability, epilepsy, developmental delay, hypotonia, …

Angelman syndrome (AS) is a rare neurodevelopmental disorder characterized by
developmental delay, impaired communication, motor deficits and ataxia, intellectual disabilities, …