Transient receptor potential channels as therapeutic targets
MM Moran, MA McAlexander, T Bíró… - Nature reviews Drug …, 2011 - nature.com
Transient receptor potential (TRP) cation channels have been among the most aggressively
pursued drug targets over the past few years. Although the initial focus of research was on …
pursued drug targets over the past few years. Although the initial focus of research was on …
A human disease model of drug toxicity–induced pulmonary edema in a lung-on-a-chip microdevice
…, KS Thorneloe, MA McAlexander… - Science translational …, 2012 - science.org
Preclinical drug development studies currently rely on costly and time-consuming animal
testing because existing cell culture models fail to recapitulate complex, organ-level disease …
testing because existing cell culture models fail to recapitulate complex, organ-level disease …
Prostaglandin-induced activation of nociceptive neurons via direct interaction with transient receptor potential A1 (TRPA1)
…, S Ghatta, MJ Carr, MA McAlexander - Molecular …, 2008 - ASPET
Inflammation contributes to pain hypersensitivity through multiple mechanisms. Among the
most well characterized of these is the sensitization of primary nociceptive neurons by …
most well characterized of these is the sensitization of primary nociceptive neurons by …
[HTML][HTML] TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis
…, A Sui, MC McKay, MA McAlexander… - The FASEB …, 2013 - ncbi.nlm.nih.gov
Allergic contact dermatitis is a common skin disease associated with inflammation and
persistent pruritus. Transient receptor potential (TRP) ion channels in skin-innervating sensory …
persistent pruritus. Transient receptor potential (TRP) ion channels in skin-innervating sensory …
Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C‐fibres by the endogenous autacoid 4‐oxononenal
TE Taylor‐Clark, MA McAlexander… - The Journal of …, 2008 - Wiley Online Library
Transient receptor potential (TRP) A1 channels are cation channels found preferentially on
nociceptive sensory neurones, including capsaicin‐sensitive TRPV1‐expressing vagal …
nociceptive sensory neurones, including capsaicin‐sensitive TRPV1‐expressing vagal …
Real-time quantitative PCR and droplet digital PCR for plant miRNAs in mammalian blood provide little evidence for general uptake of dietary miRNAs: limited …
Evidence that exogenous dietary miRNAs enter the bloodstream and tissues of ingesting
animals has been accompanied by an indication that at least one plant miRNA, miR168, …
animals has been accompanied by an indication that at least one plant miRNA, miR168, …
[HTML][HTML] Comparison of methods for miRNA extraction from plasma and quantitative recovery of RNA from cerebrospinal fluid
MA McAlexander, MJ Phillips, KW Witwer - Frontiers in genetics, 2013 - frontiersin.org
Interest in extracellular RNA (exRNA) has intensified as evidence accumulates that these
molecules may be useful as indicators of a wide variety of biological conditions. To establish …
molecules may be useful as indicators of a wide variety of biological conditions. To establish …
Transient receptor potential ankyrin 1 mediates toluene diisocyanate–evoked respiratory irritation
…, F Kiros, MJ Carr, MA McAlexander - American journal of …, 2009 - atsjournals.org
… Cells were removed from their culture flasks by treatment with Accutase (Sigma), then plated
onto poly-D-lysine–coated cover slips (BD Biosciences, Bedford, MA) and incubated at 37C …
onto poly-D-lysine–coated cover slips (BD Biosciences, Bedford, MA) and incubated at 37C …
Curcumin ((E, E)-1, 7-bis (4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3, 5-dione) activates and desensitizes the nociceptor ion channel TRPA1
AW Leamy, P Shukla, MA McAlexander, MJ Carr… - Neuroscience …, 2011 - Elsevier
The ion channel TRPA1 is activated by a wide variety of noxious stimuli, such as pollutants,
products of oxidative tissue damage, and pungent natural products. Many TRPA1 activators …
products of oxidative tissue damage, and pungent natural products. Many TRPA1 activators …
Transient receptor potential vanilloid 4 activation constricts the human bronchus via the release of cysteinyl leukotrienes
MA McAlexander, MA Luttmann, GE Hunsberger… - … of Pharmacology and …, 2014 - ASPET
Prior studies have demonstrated that the ion channel transient receptor potential vanilloid 4 (TRPV4)
is functionally expressed in airway smooth muscle cells and that TRPV4 single …
is functionally expressed in airway smooth muscle cells and that TRPV4 single …