▪ Abstract Comparative modeling predicts the three-dimensional structure of a given protein
sequence (target) based primarily on its alignment to one or more proteins of known …

The shapes of most protein sequences will be modeled based on their similarity to experimentally
determined protein structures. The current role, limitations, challenges and prospects …

How DNA is organized in three dimensions inside the cell nucleus and how this affects the
ways in which cells access, read and interpret genetic information are among the longest …

The detection of osmotic stimuli is essential for all organisms, yet few osmoreceptive proteins
are known, none of them in vertebrates. By employing a candidate-gene approach based …

Chronic lymphocytic leukemia (CLL) is a frequent hematological neoplasm in which
underlying epigenetic alterations are only partially understood. Here, we analyze the reference …

The following resources for comparative protein structure modeling and analysis are described
( http://salilab.org ): MODELLER, a program for comparative modeling by satisfaction of …

We have determined the three-dimensional (3D) architecture of the Caulobacter crescentus
genome by combining genome-wide chromatin interaction detection, live-cell imaging, and …

We developed a general approach that combines chromosome conformation capture carbon
copy (5C) with the Integrated Modeling Platform (IMP) to generate high-resolution three-…

The human genome is segmented into topologically associating domains (TADs), but the role
of this conserved organization during transient changes in gene expression is not known. …

Chromosomal architecture is known to influence gene expression, yet its role in controlling
cell fate remains poorly understood. Reprogramming of somatic cells into pluripotent stem …