[HTML][HTML] Race and genetic ancestry in medicine—a time for reckoning with racism

…, JR Rodríguez-Santana, MA Lenoir… - … England Journal of …, 2021 - Mass Medical Soc
Race and Genetic Ancestry in Medicine US health inequities won’t be eliminated by
abandoning the use of race and ethnicity in research and clinical practice, since these variables …

Early-life air pollution and asthma risk in minority children. The GALA II and SAGE II studies

…, A Davis, MA LeNoir… - American journal of …, 2013 - atsjournals.org
Rationale: Air pollution is a known asthma trigger and has been associated with short-term
asthma symptoms, airway inflammation, decreased lung function, and reduced response to …

Differential methylation between ethnic sub-groups reflects the effect of genetic ancestry and environmental exposures

…, PC Avila, E Brigino-Buenaventura, MA LeNoir… - elife, 2017 - elifesciences.org
10.7554/eLife.20532.001 Populations are often divided categorically into distinct racial/ethnic
groups based on social rather than biological constructs. Genetic ancestry has been …

Childhood obesity and asthma control in the GALA II and SAGE II studies

…, E Brigino-Buenaventura, MA LeNoir… - American journal of …, 2013 - atsjournals.org
Rationale: Obesity is associated with increased asthma morbidity, lower drug responsiveness
to inhaled corticosteroids, and worse asthma control. However, most prior investigations …

Whole-genome sequencing of pharmacogenetic drug response in racially diverse children with asthma

…, HJ Farber, K Meade, MA Lenoir… - American journal of …, 2018 - atsjournals.org
Rationale: Albuterol, a bronchodilator medication, is the first-line therapy for asthma worldwide.
There are significant racial/ethnic differences in albuterol drug response. Objectives: To …

Socioeconomic status and childhood asthma in urban minority youths. The GALA II and SAGE II studies

…, C Eng, A Davis, K Meade, MA LeNoir… - American journal of …, 2013 - atsjournals.org
Rationale: The burden of asthma is highest among socioeconomically disadvantaged
populations; however, its impact is differentially distributed among racial and ethnic groups. …

Genetic ancestry influences asthma susceptibility and lung function among Latinos

…, D Serebrisky, K Bibbins-Domingo, MA Lenoir… - Journal of Allergy and …, 2015 - Elsevier
Background Childhood asthma prevalence and morbidity varies among Latinos in the
United States, with Puerto Ricans having the highest and Mexicans the lowest. Objective To …

Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: the Genes-environments & Admixture in Latino Americans …

…, PC Avila, E Brigino-Buenaventura, MA LeNoir… - Journal of Allergy and …, 2014 - Elsevier
Background Asthma is a complex disease with both genetic and environmental causes.
Genome-wide association studies of asthma have mostly involved European populations, and …

A genome-wide association study of bronchodilator response in Latinos implicates rare variants

…, R Chapela, JG Ford, MA LeNoir… - Journal of allergy and …, 2014 - Elsevier
Background The primary rescue medication to treat acute asthma exacerbation is the short-acting
β 2 -adrenergic receptor agonist; however, there is variation in how well a patient …

Obesity and bronchodilator response in black and Hispanic children and adolescents with asthma

…, SS Oh, C Eng, A Davis, K Meade, MA LeNoir… - Chest, 2015 - Elsevier
BACKGROUND Obesity is associated with poor asthma control, increased asthma morbidity,
and decreased response to inhaled corticosteroids. We hypothesized that obesity would be …