… Thus, startle plasticity is an ideal candidate for translational research, as is illustrated in
this review and the two reviews that follow (Geyer et al. 2001; Swerdlow et al. 2001d, both this …

… [MA Geyer, unpublished results; but see Weiss and Feldon (2001), this issue]. In addition,
the combination of isolation rearing and post-weaning exposure to water deprivation leads to …

… Geyer MA: Heterogenous functions of discrete serotonergic pathways in brain, in Usdin E,
Mandell AJ (eds): New Vistas in the Biochemistry of Mental Disorders. New York, Marcel …

The most commonly cited descriptions of the behavioral characteristics of habituation come
from two papers published almost 40 years ago [Groves, PM, & Thompson, RF (1970). …

Rationale: Sensorimotor gating of the startle reflex can be assessed across species, using
similar stimuli to elicit similar responses. Prepulse inhibition (PPI), a measure of sensorimotor …

• Schizophrenic patients exhibit impairments in both sensorimotor gating and habituation in
a number of paradigms. Through human and animal model research, these fundamental …

Studies of psychiatric disorders have traditionally focused on emotional symptoms such as
depression, anxiety and hallucinations. However, poorly controlled cognitive deficits are …

Psychiatric researchers need specific animal models to better understand the neurobiology
of schizophrenia. Prepulse inhibition (PPI), the reduction in startle produced by a prepulse …

Certain animal models can greatly enhance our understanding of the neurobiology of
schizophrenia and can be used to predict the antipsychotic activity of compounds. Prepulse …

Prepulse inhibition is a cross-species phenomenon in which reflex responses to discrete
sensory events are modified by weak prestimulation. In experiments designed to investigate the …