User profiles for M. A. Bakowski

Malina A. Bakowski

Principal Investigator, California Institute for Biomedical Research
Verified email at calibr.org
Cited by 3653

Salmonella‐Containing Vacuoles: Directing Traffic and Nesting to Grow

MA Bakowski, V Braun, JH Brumell - Traffic, 2008 - Wiley Online Library
Salmonella enterica serovar Typhimurium (S. typhimurium) is a gram‐negative facultative
intracellular pathogen that can infect a broad range of mammalian hosts. Following invasion of …

Alternative splicing of conserved exons is frequently species-specific in human and mouse

Q Pan, MA Bakowski, Q Morris, W Zhang, BJ Frey… - Trends in Genetics, 2005 - cell.com
In this article, we provide evidence that a frequent source of diversity between mammalian
transcripts occurs as a consequence of species-specific alternative splicing (AS) of conserved …

[HTML][HTML] Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

…, D Arenson, L Aschenbrenner, MA Bakowski… - Nature …, 2021 - nature.com
COVID-19 caused by the SARS-CoV-2 virus has become a global pandemic. 3CL protease
is a virally encoded protein that is essential across a broad spectrum of coronaviruses with …

[HTML][HTML] Autophagy controls Salmonella infection in response to damage to the Salmonella-containing vacuole

CL Birmingham, AC Smith, MA Bakowski… - Journal of Biological …, 2006 - ASBMB
Salmonella enterica serovar Typhimurium (S. Typhimurium) is a facultative intracellular
pathogen that causes disease in a variety of hosts. S. Typhimurium actively invade host cells and …

Microsporidian genome analysis reveals evolutionary strategies for obligate intracellular growth

…, MA Bakowski, J Goldberg, AT Ma… - Genome …, 2012 - genome.cshlp.org
Microsporidia comprise a large phylum of obligate intracellular eukaryotes that are fungal-related
parasites responsible for widespread disease, and here we address questions about …

[HTML][HTML] The functional landscape of mouse gene expression

W Zhang, QD Morris, R Chang, O Shai, MA Bakowski… - Journal of biology, 2004 - Springer
Background Large-scale quantitative analysis of transcriptional co-expression has been
used to dissect regulatory networks and to predict the functions of new genes discovered by …

[HTML][HTML] Drug repurposing screens identify chemical entities for the development of COVID-19 interventions

MA Bakowski, N Beutler, KC Wolff… - Nature …, 2021 - nature.com
The ongoing pandemic caused by the novel severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2), necessitates strategies to identify prophylactic and therapeutic drug …

Discovery of a novel inhibitor of coronavirus 3CL protease for the potential treatment of COVID-19

…, D Arenson, L Aschenbrenner, MA Bakowski… - BioRxiv, 2020 - biorxiv.org
COVID-19 caused by the SARS-CoV-2 virus has become a global pandemic. 3CL protease
is a virally encoded protein that is essential to the viral life cycle across a broad spectrum of …

[HTML][HTML] Ubiquitin-Mediated Response to Microsporidia and Virus Infection in C. elegans

MA Bakowski, CA Desjardins, MG Smelkinson… - PLoS …, 2014 - journals.plos.org
Microsporidia comprise a phylum of over 1400 species of obligate intracellular pathogens
that can infect almost all animals, but little is known about the host response to these parasites…

[PDF][PDF] The phosphoinositide phosphatase SopB manipulates membrane surface charge and trafficking of the Salmonella-containing vacuole

MA Bakowski, V Braun, GY Lam, T Yeung, W Do Heo… - Cell host & …, 2010 - cell.com
Shifts in electrostatic surface charge of membranes have recently been highlighted as a
significant factor contributing to protein targeting to the plasma membrane and nascent …