Dried blood spot methods in therapeutic drug monitoring: methods, assays, and pitfalls

…, J van der Heijden, LML Stolk - Therapeutic drug …, 2009 - journals.lww.com
This article reviews dried blood spot (DBS) sampling in therapeutic drug monitoring. The
DBS method involves applying whole blood obtained via a fingerprick to a sampling paper. …

Past, present, and future of annexin A5: from protein discovery to clinical applications

…, LML Stolk, A Bennaghmouch, L Hofstra… - Journal of nuclear …, 2005 - Soc Nuclear Med
In this article, we review the clinical aspects of imaging with the programmed cell–detecting
protein annexin A5 (anxA5). AnxA5 binds to phosphatidylserine, which is one of the “eat me” …

Official international association for therapeutic drug monitoring and clinical toxicology guideline: development and validation of dried blood spot–based methods for …

…, BCP Koch, R Linden, C Pistos, LM Stolk… - Therapeutic Drug …, 2019 - journals.lww.com
… Furthermore, the stability of the stock solutions used for the spiking of the calibrators and
QCs should be guaranteed. Particular points of attention during prevalidation for DBS-based …

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

…, P Soininen, L Stolk, K Strauch, ES Tai, L Tarantini… - Nature, 2017 - nature.com
Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at
risk of developing type 2 diabetes, cardiovascular disease and related metabolic and …

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

…, M Marongiu, PF McArdle, AV Smith, L Stolk… - Nature …, 2010 - nature.com
To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide
association studies in 87,802 women of European descent, with replication in up to 14,731 …

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

…, IM Nolte, L Paternoster, E Porcu, AV Smith, L Stolk… - Nature, 2014 - nature.com
Age at menarche is a marker of timing of puberty in females. It varies widely between
individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, …

[HTML][HTML] The transcriptional landscape of age in human peripheral blood

…, F Rivadeneira, J Van Rooij, L Stolk, L Broer… - Nature …, 2015 - nature.com
Disease incidences increase with age, but the molecular characteristics of ageing that lead
to increased disease susceptibility remain inadequately understood. Here we perform a …

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

…, LM Rose, KE Schraut, AV Segrè, AV Smith, L Stolk… - Nature …, 2017 - nature.com
The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated
with various adult diseases. Using 1000 Genomes Project–imputed genotype data in up to …

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

…, KL Lunetta, N Pervjakova, DI Chasman, L Stolk… - Nature …, 2015 - nature.com
Menopause timing has a substantial impact on infertility and risk of disease, including breast
cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in …

High bone mineral density and fracture risk in type 2 diabetes as skeletal complications of inadequate glucose control: the Rotterdam Study

…, MC Castaño-Betancourt, K Estrada, L Stolk… - Diabetes …, 2013 - Am Diabetes Assoc
OBJECTIVE Individuals with type 2 diabetes have increased fracture risk despite higher
bone mineral density (BMD). Our aim was to examine the influence of glucose control on …