Antisense transcription, which was initially considered by many as transcriptional noise, is
increasingly being recognized as an important regulator of gene expression. It is widespread …

Several studies have shown that promoters of protein-coding genes are origins of pervasive
non-coding RNA transcription and can initiate transcription in both directions. However, only …

Diversified farming systems are proposed as a major mechanism to address the many
sustainability issues of today's agriculture. Multi-species livestock farming, ie keeping two or more …

Progression through the eukaryotic cell cycle is known to be both regulated and accompanied
by periodic fluctuation in the expression levels of numerous genes. We report here the …

RNA-binding proteins (RBPs) determine RNA fate from synthesis to decay. Employing two
complementary protocols for covalent UV crosslinking of RBPs to RNA, we describe a …

INTRODUCTION Genetic interactions occur when mutations in two or more genes combine
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …

Genome-wide pervasive transcription has been reported in many eukaryotic organisms 1 , 2
, 3 , 4 , 5 , 6 , 7 , revealing a highly interleaved transcriptome organization that involves …

Blood formation is believed to occur through stepwise progression of haematopoietic stem
cells (HSCs) following a tree-like hierarchy of oligo-, bi-and unipotent progenitors. However, …

Deleting a gene in an organism often has little phenotypic effect 1 , 2 , 3 , 4 , 5 , owing to two
mechanisms of compensation 4 , 5 , 6 , 7 , 8 , 9 , 10 . The first is the existence of duplicate …

There is abundant transcription from eukaryotic genomes unaccounted for by protein coding
genes. A high-resolution genome-wide survey of transcription in a well annotated genome …