User profiles for L. Quintana-Murci

Lluis Quintana-Murci

Collège de France and Institut Pasteur (CNRS UMR2000)
Verified email at pasteur.fr
Cited by 28569

From evolutionary genetics to human immunology: how selection shapes host defence genes

LB Barreiro, L Quintana-Murci - Nature Reviews Genetics, 2010 - nature.com
Pathogens have always been a major cause of human mortality, so they impose strong
selective pressure on the human genome. Data from population genetic studies, including …

[HTML][HTML] Sexual inequality in tuberculosis

O Neyrolles, L Quintana-Murci - PLoS medicine, 2009 - journals.plos.org
… Lluis Quintana-Murci … Lluis Quintana-Murci … Copyright: © 2009 Neyrolles, Quintana-Murci.
This is an open-access article distributed under the terms of the Creative Commons …

Human TLRs and IL-1Rs in host defense: natural insights from evolutionary, epidemiological, and clinical genetics

…, L Abel, L Quintana-Murci - Annual review of …, 2011 - annualreviews.org
… Laval, and L. Quintana-Murci, manuscript in preparation). The protein products of these
genes have been constrained to various degrees by evolution, and adaptors therefore generally …

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

…, D Duffy, L Quintana-Murci, D Van De Beek, L Roussel… - Science, 2020 - science.org
INTRODUCTION Interindividual clinical variability is vast in humans infected with severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ranging from silent infection to rapid …

TLR3 deficiency in patients with herpes simplex encephalitis

…, P Lebon, B Héron, L Vallée, L Quintana-Murci… - science, 2007 - science.org
Some Toll and Toll-like receptors (TLRs) provide immunity to experimental infections in
animal models, but their contribution to host defense in natural ecosystems is unknown. We …

Natural selection has driven population differentiation in modern humans

…, G Laval, H Quach, E Patin, L Quintana-Murci - Nature …, 2008 - nature.com
The considerable range of observed phenotypic variation in human populations may reflect,
in part, distinctive processes of natural selection and adaptation to variable environmental …

[HTML][HTML] An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease

…, BD Jamieson, D Sun, S Li, W Chen, L Quintana-Murci… - Genome biology, 2016 - Springer
Background Epigenetic biomarkers of aging (the “epigenetic clock”) have the potential to
address puzzling findings surrounding mortality rates and incidence of cardio-metabolic …

[HTML][HTML] The dawn of human matrilineal diversity

…, D Comas, J Bertranpetit, L Quintana-Murci… - The American Journal of …, 2008 - cell.com
… We evaluated all 315 Hg L(xM,N) complete mtDNA sequences reported in the literature. …
Next, we identified all Hg L(xM,N) samples in all population sample collections available in …

Genetic evidence of an early exit of Homo sapiens sapiens from Africa through eastern Africa

L Quintana-Murci, O Semino, HJ Bandelt, G Passarino… - Nature …, 1999 - nature.com
The out-of-Africa scenario 1 has hitherto provided little evidence for the precise route by
which modern humans left Africa. Two major routes of dispersal have been hypothesized: one …

[HTML][HTML] Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense

…, L Abel, JL Casanova, L Quintana-Murci - PLoS …, 2009 - journals.plos.org
Infectious diseases have been paramount among the threats to health and survival throughout
human evolutionary history. Natural selection is therefore expected to act strongly on host …