User profiles for L. Quintana-Murci
Lluis Quintana-MurciCollège de France and Institut Pasteur (CNRS UMR2000) Verified email at pasteur.fr Cited by 28569 |
From evolutionary genetics to human immunology: how selection shapes host defence genes
LB Barreiro, L Quintana-Murci - Nature Reviews Genetics, 2010 - nature.com
Pathogens have always been a major cause of human mortality, so they impose strong
selective pressure on the human genome. Data from population genetic studies, including …
selective pressure on the human genome. Data from population genetic studies, including …
[HTML][HTML] Sexual inequality in tuberculosis
O Neyrolles, L Quintana-Murci - PLoS medicine, 2009 - journals.plos.org
… Lluis Quintana-Murci … Lluis Quintana-Murci … Copyright: © 2009 Neyrolles, Quintana-Murci.
This is an open-access article distributed under the terms of the Creative Commons …
This is an open-access article distributed under the terms of the Creative Commons …
Human TLRs and IL-1Rs in host defense: natural insights from evolutionary, epidemiological, and clinical genetics
…, L Abel, L Quintana-Murci - Annual review of …, 2011 - annualreviews.org
… Laval, and L. Quintana-Murci, manuscript in preparation). The protein products of these
genes have been constrained to various degrees by evolution, and adaptors therefore generally …
genes have been constrained to various degrees by evolution, and adaptors therefore generally …
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
…, D Duffy, L Quintana-Murci, D Van De Beek, L Roussel… - Science, 2020 - science.org
INTRODUCTION Interindividual clinical variability is vast in humans infected with severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ranging from silent infection to rapid …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ranging from silent infection to rapid …
TLR3 deficiency in patients with herpes simplex encephalitis
…, P Lebon, B Héron, L Vallée, L Quintana-Murci… - science, 2007 - science.org
Some Toll and Toll-like receptors (TLRs) provide immunity to experimental infections in
animal models, but their contribution to host defense in natural ecosystems is unknown. We …
animal models, but their contribution to host defense in natural ecosystems is unknown. We …
Natural selection has driven population differentiation in modern humans
The considerable range of observed phenotypic variation in human populations may reflect,
in part, distinctive processes of natural selection and adaptation to variable environmental …
in part, distinctive processes of natural selection and adaptation to variable environmental …
[HTML][HTML] An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease
…, BD Jamieson, D Sun, S Li, W Chen, L Quintana-Murci… - Genome biology, 2016 - Springer
Background Epigenetic biomarkers of aging (the “epigenetic clock”) have the potential to
address puzzling findings surrounding mortality rates and incidence of cardio-metabolic …
address puzzling findings surrounding mortality rates and incidence of cardio-metabolic …
[HTML][HTML] The dawn of human matrilineal diversity
… We evaluated all 315 Hg L(xM,N) complete mtDNA sequences reported in the literature. …
Next, we identified all Hg L(xM,N) samples in all population sample collections available in …
Next, we identified all Hg L(xM,N) samples in all population sample collections available in …
Genetic evidence of an early exit of Homo sapiens sapiens from Africa through eastern Africa
The out-of-Africa scenario 1 has hitherto provided little evidence for the precise route by
which modern humans left Africa. Two major routes of dispersal have been hypothesized: one …
which modern humans left Africa. Two major routes of dispersal have been hypothesized: one …
[HTML][HTML] Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense
…, L Abel, JL Casanova, L Quintana-Murci - PLoS …, 2009 - journals.plos.org
Infectious diseases have been paramount among the threats to health and survival throughout
human evolutionary history. Natural selection is therefore expected to act strongly on host …
human evolutionary history. Natural selection is therefore expected to act strongly on host …