We found that several transposable elements were highly active in Drosophila brain during
normal aging. In addition, we found that mutations in Drosophila Argonaute 2 (Ago2) resulted …

… used as the normalization factor, ie, L i ≈e i * L r where L r is the reference library, L i is
one other library, and e i is the correlation coefficient of library L i to L r . Figure S1B shows the …

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are two
incurable neurodegenerative disorders that exist on a symptomological spectrum and share …

Degradative fragments of cartilage oligomeric matrix protein (COMP) have been observed
in arthritic patients. The physiological enzyme (s) that degrade COMP, however, remain …

Mutations in the human cartilage oligomeric matrix protein (COMP) gene have been linked
to the development of pseudoachondroplasia and multiple epiphyseal dysplasia. We …

Evidence is rapidly mounting that transposable element (TE) expression and replication
may impact biology more widely than previously thought. This includes potential effects on …

The relatively simple combinatorial rules responsible for establishing the initial metameric
expression of sloppy-paired-1 (slp1) in the Drosophila blastoderm embryo make this system …

The differentiation of uncommitted mesenchymal cells into osteoblasts is a fundamental
molecular event governing both embryonic development and bone repair. The bone …

A hallmark of genes that are subject to developmental regulation of transcriptional elongation
is association of the negative elongation factor NELF with the paused RNA polymerase …

… Wu, Chung-Hsiu MD; Prazak, Ladislao M. MD … TEL: (Int’l): …