Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control

I Barbieri, K Tzelepis, L Pandolfini, J Shi… - Nature, 2017 - nature.com
N 6 -methyladenosine (m 6 A) is an abundant internal RNA modification in both coding 1
and non-coding RNAs 2 , 3 that is catalysed by the METTL3–METTL14 methyltransferase …

[PDF][PDF] METTL1 promotes let-7 MicroRNA processing via m7G methylation

L Pandolfini, I Barbieri, AJ Bannister, A Hendrick… - Molecular cell, 2019 - cell.com
7-methylguanosine (m7G) is present at mRNA caps and at defined internal positions within
tRNAs and rRNAs. However, its detection within low-abundance mRNAs and microRNAs (…

Enhanced recovery pathways in colorectal surgery: a consensus paper by the Associazione Chirurghi Ospedalieri Italiani (ACOI) and the PeriOperative Italian Society …

…, A Maurizi, R Monzani, U Pace, L Pandolfini… - Il Giornale di …, 2019 - europepmc.org
Enhanced Recovery After Surgery (ERAS) pathway is a multi-disciplinary, patient-centered
protocol relying on the implementation of the best evidence-based perioperative practice. In …

[HTML][HTML] RNA modifications detection by comparative Nanopore direct RNA sequencing

A Leger, PP Amaral, L Pandolfini, C Capitanchik… - Nature …, 2021 - nature.com
RNA molecules undergo a vast array of chemical post-transcriptional modifications (PTMs)
that can affect their structure and interaction properties. In recent years, a growing number of …

[HTML][HTML] Longitudinal RNA-Seq analysis of vertebrate aging identifies mitochondrial complex I as a small-molecule-sensitive modifier of lifespan

…, M Groth, N Hartmann, U Menzel, L Pandolfini… - Cell Systems, 2016 - cell.com
Mutations and genetic variability affect gene expression and lifespan, but the impact of
variations in gene expression within individuals on their aging-related mortality is poorly …

[HTML][HTML] Genomic positional conservation identifies topological anchor point RNAs linked to developmental loci

…, R Arias-Carrasco, M Büscher, L Pandolfini… - Genome biology, 2018 - Springer
Background The mammalian genome is transcribed into large numbers of long noncoding
RNAs (lncRNAs), but the definition of functional lncRNA groups has proven difficult, partly due …

The non-coding epitranscriptome in cancer

V Miano, A Codino, L Pandolfini… - Briefings in functional …, 2021 - academic.oup.com
… This work was supported by IIT funding to Azzurra Codino and Luca Pandolfini. … Luca
Pandolfini was a postdoctoral fellow at the Gurdon Institute (University of Cambridge). He is now a …

[HTML][HTML] LINE-1 regulates cortical development by acting as long non-coding RNAs

…, D Vozzi, F Persichetti, C Santoro, L Pandolfini… - Nature …, 2023 - nature.com
Long Interspersed Nuclear Elements-1s (L1s) are transposable elements that constitute
most of the genome’s transcriptional output yet have still largely unknown functions. Here we …

[HTML][HTML] MicroRNA miR-29 controls a compensatory response to limit neuronal iron accumulation during adult life and aging

R Ripa, L Dolfi, M Terrigno, L Pandolfini, A Savino… - BMC biology, 2017 - Springer
Background A widespread modulation of gene expression occurs in the aging brain, but
little is known as to the upstream drivers of these changes. MicroRNAs emerged as fine …

[HTML][HTML] SINEUP non-coding RNA activity depends on specific N6-methyladenosine nucleotides

…, S Espinoza, P Valentini, L Pandolfini… - … Therapy-Nucleic Acids, 2023 - cell.com
SINEUPs are natural and synthetic antisense long non-coding RNAs (lncRNAs) selectively
enhancing target mRNAs translation by increasing their association with polysomes. This …