User profiles for L. Moutsianas
 | Loukas MoutsianasGenomics England Verified email at genomicsengland.co.uk Cited by 27345 |
[HTML][HTML] Genetic mechanisms of critical illness in COVID-19
, … Barclay L. 45 Hope D. 45 McCulloch C. 45 McQuillan L … - Nature, 2021 - nature.com
Host-mediated lung inflammation is present 1 , and drives mortality 2 , in the critical illness
caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with …
caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with …
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
…, C McCabe, IL Mero, J Mescheriakova, L Moutsianas… - Nature …, 2013 - nature.com
Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple
sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 …
sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 …
[HTML][HTML] Genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1
… Joyce Leman, 22 Stephen Leslie, 12 Lotus Mallbris, 23 Hugh S Markus, 24 Christopher G
Mathew, 2 WH Irwin McLean, 25 Ross McManus, 27 Rotraut Mössner, 28 Loukas Moutsianas, …
Mathew, 2 WH Irwin McLean, 25 Ross McManus, 27 Rotraut Mössner, 28 Loukas Moutsianas, …
The genetic architecture of type 2 diabetes
The genetic architecture of common traits, including the number, frequency, and effect sizes
of inherited variants that contribute to individual risk, has been long debated. Genome-wide …
of inherited variants that contribute to individual risk, has been long debated. Genome-wide …
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease
Genetic association studies have identified 215 risk loci for inflammatory bowel disease 1 ,
2 , 3 , 4 , 5 , 6 , 7 , 8 , thereby uncovering fundamental aspects of its molecular biology. We …
2 , 3 , 4 , 5 , 6 , 7 , 8 , thereby uncovering fundamental aspects of its molecular biology. We …
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
…, M Pirinen, MA Stone, L Appleton, L Moutsianas… - Nature …, 2011 - nature.com
… In the version of this article initially published, the name of author Udo Oppermann was
incorrectly spelled as Udo Opperman, and the name of author Loukas Moutsianas was …
incorrectly spelled as Udo Opperman, and the name of author Loukas Moutsianas was …
[HTML][HTML] Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders
Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying
susceptibility genes could highlight the underlying pathophysiological mechanisms. We …
susceptibility genes could highlight the underlying pathophysiological mechanisms. We …
[HTML][HTML] HLA-DQA1* 05 carriage associated with development of anti-drug antibodies to infliximab and adalimumab in patients with Crohn's disease
Background & Aims Anti–tumor necrosis factor (anti-TNF) therapies are the most widely
used biologic drugs for treating immune-mediated diseases, but repeated administration can …
used biologic drugs for treating immune-mediated diseases, but repeated administration can …
Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7
To further resolve the genetic architecture of the inflammatory bowel diseases ulcerative
colitis and Crohn's disease, we sequenced the whole genomes of 4,280 patients at low …
colitis and Crohn's disease, we sequenced the whole genomes of 4,280 patients at low …
Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes
Peroxisome proliferator-activated receptor gamma (PPARG) is a master transcriptional
regulator of adipocyte differentiation and a canonical target of antidiabetic thiazolidinedione …
regulator of adipocyte differentiation and a canonical target of antidiabetic thiazolidinedione …