As sequencing technologies become more affordable, it is now realistic to propose studying
the evolutionary history of virtually any organism on a genomic scale. However, when …

The molecular landscape in non-muscle-invasive bladder cancer (NMIBC) is characterized
by large biological heterogeneity with variable clinical outcomes. Here, we perform an …

The human genome is generally organized into stable chromosomes, and only tumor cells
are known to accumulate kilobase (kb)-sized extrachromosomal circular DNA elements (…

Metallothionein (MT)‐I+II synthesis is induced in the central nervous system (CNS) in response
to practically any pathogen or disorder, where it is increased mainly in reactive glia. MT‐I…

Hundreds of thousands of human genomes are now being sequenced to characterize genetic
variation and use this information to augment association mapping studies of complex …

RNA sequencing allows for simultaneous transcript discovery and quantification, but
reconstructing complete transcripts from such data remains difficult. Here, we introduce …

Background Circular DNA has recently been identified across different species including
human normal and cancerous tissue, but short-read mappers are unable to align many of the …

Genotype estimates from short-read sequencing data are typically based on the alignment
of reads to a linear reference, but reads originating from more complex variants (for example, …

Highly fluorescent silver nanoparticles (AgFNP) have been prepared by a facile
photochemical method, yielding these materials in just a few minutes and with excellent long-term …

Sequencing of cell-free DNA (cfDNA) is currently being used to detect cancer by searching
both for mutational and non-mutational alterations. Recent work has shown that the length …