In response to stress, the central nervous system initiates a signaling cascade, which leads
to the production of glucocorticoids (GCs). GCs act through the glucocorticoid receptor (GR) …

Networks of coordinated alternative splicing (AS) events play critical roles in development
and disease. However, a comprehensive knowledge of the factors that regulate these …

Although widely prescribed for their potent antiinflammatory actions, glucocorticoid drugs (eg,
dexamethasone) cause undesirable side effects that are features of the metabolic …

Hormones such as fibroblast growth factor 21 (FGF21) and glucocorticoids (GCs) play crucial
roles in coordinating the adaptive starvation response. Here we examine the interplay …

Background & Aims Little is known about the effects of the vitamin D receptor (VDR) on hepatic
activity of human cholesterol 7α-hydroxylase (CYP7A1) and cholesterol metabolism. We …

The nuclear receptor peroxisome proliferator-activated receptor alpha (PPARα) is emerging
as an important target in the brain for the treatment or prevention of cognitive disorders. The …

Long term benefits following short-term administration of high psychedelic doses of
serotonergic and dissociative hallucinogens, typified by psilocybin and ketamine respectively, …

Endothelial progenitor cells (EPCs), critical for mediating vascular repair, are dysfunctional
in a hyperglycemic and/or hypercholesterolemic environment. Their dysfunction contributes …

Bile acids are cholesterol‐derived signaling molecules that regulate mammalian metabolism
through sterol‐sensing nuclear receptor transcription factors. In C. elegans, bile acid‐like …

We recently reported that lecithin:cholesterol acyltransferase (LCAT) knock-out mice, particularly
in the LDL receptor knock-out background, are hypersensitive to insulin and resistant to …