Background Data provided by the social sciences as well as genetic research suggest that
the 8-10 million Roma (Gypsies) who live in Europe today are best described as a …

Polygenic risk scores have shown great promise in predicting complex disease risk and will
become more accurate as training sample sizes increase. The standard approach for …

Copy number variants (CNVs) have been strongly implicated in the genetic etiology of
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has …

We have conducted a genome screen of autism, by linkage analysis in an initial set of 90
multiplex sibships, with parents, containing 97 independent affected sib pairs (ASPs), with …

The Gypsies (a misnomer, derived from an early legend about Egyptian origins) defy the
conventional definition of a population: they have no nation‐state, speak different languages, …

Clinal patterns of autosomal genetic diversity within Europe have been interpreted in
previous studies in terms of a Neolithic demic diffusion model for the spread of agriculture; in …

Regulatory and coding variants are known to be enriched with associations identified by
genome-wide association studies (GWASs) of complex disease, but their contributions to trait …

The CCR5-Δ32 deletion obliterates the CCR5 chemokine and the human immunodeficiency
virus (HIV)–1 coreceptor on lymphoid cells, leading to strong resistance against HIV-1 …

We estimate an effective mutation rate at an average Y chromosome short-tandem repeat
locus as 6.9×10 −4 per 25 years, with a standard deviation across loci of 5.7×10 −4 , using …

ΔF508 is the most frequent cystic fibrosis (CF) mutation and accounts for approximately 70%
of CF chromosomes worldwide. Three highly polymorphic microsatellite markers have been …