… Lili Fuhr: Amongst scientists and activists, there is a consensus that we need to go beyond
reducing emissions and that the most effective strategy is to phase out all fossil fuels as fast as …

The circadian clock is a powerful endogenous timing system, which allows organisms to fine-tune
their physiology and behaviour to the geophysical time. The interplay of a distinct set …

Introduction Adverse drug reactions (ADRs) are among the leading causes of death, and
frequently associated with drug–gene interactions (DGIs). In addition to pharmacogenomic …

Resveratrol has gained tremendous interest owing to multiple reported health-beneficial
effects. However, the underlying key mechanism of action of this natural product remained …

An endogenous molecular clockwork drives various cellular pathways including metabolism
and the cell cycle. Its dysregulation is able to prompt pathological phenotypes including …

Amorfrutins are isoprenoid-substituted benzoic acid derivatives, which were found in
Amorpha fruticosa L. (bastard indigo) and in Glycyrrhiza foetida Desf. (licorice). Recently, …

… the ATP-synthase inhibitor oligomycin was added (OCR O/L ) followed by addition of 0.2 μM
of the … − OCR O/L is a measure of the respiratory activity linked to the ATP-synthesis and the …

The mammalian circadian clock and the cell cycle are two major biological oscillators
whose coupling influences cell fate decisions. In the present study, we use a model-driven …

Physiology of living beings show circadian rhythms entrained by a central timekeeper present
in the hypothalamic suprachiasmatic nuclei. Nevertheless, virtually all peripheral tissues …

The anticonvulsant carbamazepine is frequently used in the long-term therapy of epilepsy
and is a known substrate and inducer of cytochrome P450 (CYP) 3A4 and CYP2B6. …