User profiles for L. Franke
Lude FrankeProfessor of Functional Genomics, University Medical Centre Groningen Verified email at cleverfranke.com Cited by 86253 |
Identification of novel autism candidate regions through analysis of reported cytogenetic abnormalities associated with autism
…, H Van Engeland, PFR Hochstenbach, L Franke - Molecular …, 2006 - nature.com
The identification of the candidate genes for autism through linkage and association studies
has proven to be a difficult enterprise. An alternative approach is the analysis of cytogenetic …
has proven to be a difficult enterprise. An alternative approach is the analysis of cytogenetic …
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption
…, A Rasheed, MA Mason, AB Zonderman, L Franke… - Molecular …, 2015 - nature.com
Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in
the world and has received considerable attention regarding health risks and benefits. We …
the world and has received considerable attention regarding health risks and benefits. We …
[PDF][PDF] Modeling linkage disequilibrium increases accuracy of polygenic risk scores
…, AH Fanous, MS Farrell, J Frank, L Franke… - The american journal of …, 2015 - cell.com
Polygenic risk scores have shown great promise in predicting complex disease risk and will
become more accurate as training sample sizes increase. The standard approach for …
become more accurate as training sample sizes increase. The standard approach for …
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
Copy number variants (CNVs) have been strongly implicated in the genetic etiology of
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has …
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has …
[PDF][PDF] Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases
…, AH Fanous, MS Farrell, J Frank, L Franke… - The American Journal of …, 2014 - cell.com
Regulatory and coding variants are known to be enriched with associations identified by
genome-wide association studies (GWASs) of complex disease, but their contributions to trait …
genome-wide association studies (GWASs) of complex disease, but their contributions to trait …
[HTML][HTML] From genome to function by studying eQTLs
Genome-wide association studies (GWASs) have shown a large number of genetic variants
to be associated with complex diseases. The identification of the causal variant within an …
to be associated with complex diseases. The identification of the causal variant within an …
[PDF][PDF] Genomic dissection of bipolar disorder and schizophrenia, including 28 subphenotypes
…, M Flickinger, TM Foroud, L Forty, J Frank, L Franke… - Cell, 2018 - cell.com
Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology.
Understanding the genetic factors contributing to the shared and disorder-specific symptoms …
Understanding the genetic factors contributing to the shared and disorder-specific symptoms …
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression
Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms
on the transcriptome. To investigate the genetics of gene expression, we performed cis…
on the transcriptome. To investigate the genetics of gene expression, we performed cis…
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Genome-wide association studies and candidate gene studies in ulcerative colitis have
identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-…
identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-…
Genetics of rheumatoid arthritis contributes to biology and drug discovery
A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated
variants with diverse genomic and biological data sets to provide insight into …
variants with diverse genomic and biological data sets to provide insight into …