Importance The clinical management ofBRCA1andBRCA2mutation carriers requires accurate,
prospective cancer risk estimates. Objectives To estimate age-specific risks of breast, …

Characterized primarily by a low body-mass index, anorexia nervosa is a complex and
serious illness 1 , affecting 0.9–4% of women and 0.3% of men 2 , 3 – 4 , with twin-based …

Some autoimmune disorders are increasingly recognized as risk factors for non-Hodgkin
lymphoma (NHL) overall, but large-scale systematic assessments of risk of NHL subtypes are …

Lung cancer is the most common cause of cancer death worldwide, with over one million
cases annually 1 . To identify genetic factors that modify disease risk, we conducted a genome-…

Lung cancer is mainly caused by smoking, but the quantitative relations between smoking
and histologic subtypes of lung cancer remain inconclusive. By using one of the largest lung …

ContextGenetic testing for inherited mutations in BRCA1 and BRCA2 has become integral to
the care of women with a severe family history of breast or ovarian cancer, but an unknown …

Background Non-Hodgkin lymphoma (NHL) comprises biologically and clinically heterogeneous
subtypes. Previously, study size has limited the ability to compare and contrast the risk …

We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159
controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease …

Background Type 2 diabetes mellitus has been associated with an excess risk of pancreatic
cancer, but the magnitude of the risk and the time–risk relationship are unclear, and there is …

The prevalence and spectrum of germline mutations in BRCA1 and BRCA2 have been reported
in single populations, with the majority of reports focused on White in Europe and North …