Primary cutaneous lymphomas are currently classified by the European Organization for
Research and Treatment of Cancer (EORTC) classification or the World Health Organization (…

INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …

Interoception refers to the process by which the nervous system senses, interprets, and
integrates signals originating from within the body, providing a moment-by-moment mapping of …

Large-scale reference data sets of human genetic variation are critical for the medical and
functional interpretation of DNA sequence changes. Here we describe the aggregation and …

Identifying genetic correlations between complex traits and diseases can provide useful
etiological insights and help prioritize likely causal relationships. The major challenges …

A major challenge of biology is understanding the relationship between molecular genetic
variation and variation in quantitative traits, including fitness. This relationship determines our …

Schizophrenia is a common disease with a complex aetiology, probably involving multiple
and heterogeneous genetic factors. Here, by analysing the exome sequences of 2,536 …

Tumour-initiating cells capable of self-renewal and differentiation, which are responsible for
tumour growth, have been identified in human haematological malignancies 1 , 2 and solid …

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …

A method utilizing aminopropyl bonded phase (Bond Elut) columns has been developed to
separate lipid mixtures into individual classes in high yield and purity. Up to ten lipid mixtures …