In recent years, our understanding of the molecular pathogenesis of myeloid neoplasms,
including acute myeloid leukemia (AML), has been greatly advanced by genomics discovery …

The genetic characterization of chronic lymphocytic leukemia (CLL) has made significant
progress over the past few years. While conventional cytogenetic analyses only detected …

Background Recent studies have provided a detailed census of genes that are mutated in
acute myeloid leukemia (AML). Our next challenge is to understand how this genetic diversity …

Background Fluorescence in situ hybridization has improved the detection of genomic
aberrations in chronic lymphocytic leukemia. We used this method to identify chromosomal …

Background Mutations occur in several genes in cytogenetically normal acute myeloid
leukemia (AML) cells: the nucleophosmin gene (NPM1), the fms-related tyrosine kinase 3 gene (…

The histone 3 lysine 79 (H3K79) methyltransferase Dot1l has been implicated in the development
of leukemias bearing translocations of the Mixed Lineage Leukemia (MLL) gene. We …

Background In patients with acute myeloid leukemia (AML), the presence or absence of
recurrent cytogenetic aberrations is used to identify the appropriate therapy. However, the …

Genomic rearrangements are thought to occur progressively during tumor development.
Recent findings, however, suggest an alternative mechanism, involving massive chromosome …

To assess the prognostic relevance of mutations in the NPM1 gene encoding a nucleocytoplasmic
shuttle protein in younger adults with acute myeloid leukemia (AML) and normal …

Lenalidomide is a highly effective treatment for myelodysplastic syndrome (MDS) with
deletion of chromosome 5q (del(5q)). Here, we demonstrate that lenalidomide induces the …