… Its constraint is defined as a convex combination of the L 1 and L 2 norms of the regression
coefficients parameterized by an additional calibration parameter λ. The two extreme cases λ …

Genetic maps, which document the way in which recombination rates vary over a genome,
are an essential tool for many genetic analyses. We present a high-resolution genetic map of …

Combined analyses of gene networks and DNA sequence variation can provide new
insights into the aetiology of common diseases that may not be apparent from genome-wide …

Common multi-allelic copy number variants (CNVs) appear enriched for phenotypic associations
compared to their biallelic counterparts 1 , 2 , 3 , 4 . Here we investigated the influence …

… Among the population of chains, we identify a group L, 1 ≤ L ≤ L… First of all, we fix the size
L of the population. In doing this, we … We have experimented and we recommend to fix L ≥ 3. …

Left ventricular mass (LVM) is a highly heritable trait 1 and an independent risk factor for all-cause
mortality 2 . So far, genome-wide association studies have not identified the genetic …

Gene-regulatory network analysis is a powerful approach to elucidate the molecular
processes and pathways underlying complex disease. Here we employ systems genetics …

Genetic determinants of cognition are poorly characterized, and their relationship to genes
that confer risk for neurodevelopmental disease is unclear. Here we performed a systems-…

Background: Lipoprotein-related traits have been consistently identified as risk factors for
atherosclerotic cardiovascular disease, largely on the basis of studies of coronary artery …

Mitochondrial disorders affect 1/5,000 and have no cure. Inducing mitochondrial biogenesis
with bezafibrate improves mitochondrial function in animal models, but there are no …