User profiles for L. Botigue

Laura R Botigué

Centre for Research in Agricultural Genomics
Verified email at cragenomica.es
Cited by 3055

Estimating the mutation load in human genomes

BM Henn, LR Botigué, CD Bustamante… - Nature Reviews …, 2015 - nature.com
… (L), the reduction in fitness in a population or species attributable to the presence of alleles
that are detrimental in comparison with the genotype that has the maximum fitness (Box 1): L

A universal probe set for targeted sequencing of 353 nuclear genes from any flowering plant designed using k-medoids clustering

MG Johnson, L Pokorny, S Dodsworth… - Systematic …, 2019 - academic.oup.com
Sequencing of target-enriched libraries is an efficient and cost-effective method for obtaining
DNA sequence data from hundreds of nuclear loci for phylogeny reconstruction. Much of …

High-depth African genomes inform human migration and health

A Choudhury, S Aron, LR Botigué, D Sengupta… - Nature, 2020 - nature.com
The African continent is regarded as the cradle of modern humans and African genomes
contain more genetic variation than those from any other continent, yet only a fraction of the …

[HTML][HTML] Genomic ancestry of North Africans supports back-to-Africa migrations

BM Henn, LR Botigué, S Gravel, W Wang… - PLoS …, 2012 - journals.plos.org
… a haplotype i in the j th window as the weighted average L j g ij , where g ij is a column vector
of … L j is a matrix for which the entry in the k th row, l th column is the loading of SNP l in the …

[HTML][HTML] Ancient European dog genomes reveal continuity since the Early Neolithic

LR Botigué, S Song, A Scheu, S Gopalan… - Nature …, 2017 - nature.com
Europe has played a major role in dog evolution, harbouring the oldest uncontested Palaeolithic
remains and having been the centre of modern dog breed creation. Here we sequence …

Distance from sub-Saharan Africa predicts mutational load in diverse human genomes

…, H Cann, MP Snyder, L Excoffier… - Proceedings of the …, 2016 - National Acad Sciences
… of the load for all variants: L T = ∑ v L v . For each variant we … We calculated L T for each
HGDP population (Fig. 5). When … having the lowest mutational load (L T =2.83), followed by the …

A comprehensive phylogenomic platform for exploring the angiosperm tree of life

…, O Maurin, C Mcginnie, L Pokorny… - Systematic …, 2022 - academic.oup.com
… 400 bp, using a Covaris M220 Focused-ultrasonicator (Covaris, Woburn, MA, USA) by
adding 50 |$\mu $|L of diluted genomic DNA to a 130 |$\mu $|L Covaris microAFA tube. The …

Gene flow from North Africa contributes to differential human genetic diversity in southern Europe

LR Botigué, BM Henn, S Gravel… - Proceedings of the …, 2013 - National Acad Sciences
Human genetic diversity in southern Europe is higher than in other regions of the continent.
This difference has been attributed to postglacial expansions, the demic diffusion of …

[HTML][HTML] Genome-wide diversity in the levant reveals recent structuring by culture

M Haber, D Gauguier, S Youhanna, N Patterson… - PLoS …, 2013 - journals.plos.org
The Levant is a region in the Near East with an impressive record of continuous human
existence and major cultural developments since the Paleolithic period. Genetic and …

[HTML][HTML] North African populations carry the signature of admixture with Neandertals

F Sánchez-Quinto, LR Botigué, S Civit, C Arenas… - 2012 - journals.plos.org
One of the main findings derived from the analysis of the Neandertal genome was the
evidence for admixture between Neandertals and non-African modern humans. An alternative …