User profiles for L. Botigue
Laura R BotiguéCentre for Research in Agricultural Genomics Verified email at cragenomica.es Cited by 3055 |
Estimating the mutation load in human genomes
… (L), the reduction in fitness in a population or species attributable to the presence of alleles
that are detrimental in comparison with the genotype that has the maximum fitness (Box 1): L …
that are detrimental in comparison with the genotype that has the maximum fitness (Box 1): L …
A universal probe set for targeted sequencing of 353 nuclear genes from any flowering plant designed using k-medoids clustering
Sequencing of target-enriched libraries is an efficient and cost-effective method for obtaining
DNA sequence data from hundreds of nuclear loci for phylogeny reconstruction. Much of …
DNA sequence data from hundreds of nuclear loci for phylogeny reconstruction. Much of …
High-depth African genomes inform human migration and health
The African continent is regarded as the cradle of modern humans and African genomes
contain more genetic variation than those from any other continent, yet only a fraction of the …
contain more genetic variation than those from any other continent, yet only a fraction of the …
[HTML][HTML] Genomic ancestry of North Africans supports back-to-Africa migrations
… a haplotype i in the j th window as the weighted average L j g ij , where g ij is a column vector
of … L j is a matrix for which the entry in the k th row, l th column is the loading of SNP l in the …
of … L j is a matrix for which the entry in the k th row, l th column is the loading of SNP l in the …
[HTML][HTML] Ancient European dog genomes reveal continuity since the Early Neolithic
Europe has played a major role in dog evolution, harbouring the oldest uncontested Palaeolithic
remains and having been the centre of modern dog breed creation. Here we sequence …
remains and having been the centre of modern dog breed creation. Here we sequence …
Distance from sub-Saharan Africa predicts mutational load in diverse human genomes
…, H Cann, MP Snyder, L Excoffier… - Proceedings of the …, 2016 - National Acad Sciences
… of the load for all variants: L T = ∑ v L v . For each variant we … We calculated L T for each
HGDP population (Fig. 5). When … having the lowest mutational load (L T =2.83), followed by the …
HGDP population (Fig. 5). When … having the lowest mutational load (L T =2.83), followed by the …
A comprehensive phylogenomic platform for exploring the angiosperm tree of life
… 400 bp, using a Covaris M220 Focused-ultrasonicator (Covaris, Woburn, MA, USA) by
adding 50 |$\mu $|L of diluted genomic DNA to a 130 |$\mu $|L Covaris microAFA tube. The …
adding 50 |$\mu $|L of diluted genomic DNA to a 130 |$\mu $|L Covaris microAFA tube. The …
Gene flow from North Africa contributes to differential human genetic diversity in southern Europe
Human genetic diversity in southern Europe is higher than in other regions of the continent.
This difference has been attributed to postglacial expansions, the demic diffusion of …
This difference has been attributed to postglacial expansions, the demic diffusion of …
[HTML][HTML] Genome-wide diversity in the levant reveals recent structuring by culture
The Levant is a region in the Near East with an impressive record of continuous human
existence and major cultural developments since the Paleolithic period. Genetic and …
existence and major cultural developments since the Paleolithic period. Genetic and …
[HTML][HTML] North African populations carry the signature of admixture with Neandertals
One of the main findings derived from the analysis of the Neandertal genome was the
evidence for admixture between Neandertals and non-African modern humans. An alternative …
evidence for admixture between Neandertals and non-African modern humans. An alternative …