[PDF][PDF] Rational design of evolutionarily stable microbial kill switches

F Stirling, L Bitzan, S O'Keefe, E Redfield, JWK Oliver… - Molecular cell, 2017 - cell.com
The evolutionary stability of synthetic genetic circuits is key to both the understanding and
application of genetic control elements. One useful but challenging situation is a switch …

Cellular and extracellular white matter alterations indicate conversion to psychosis among individuals at clinical high-risk for psychosis

FL Nägele, O Pasternak, LV Bitzan… - The World Journal of …, 2021 - Taylor & Francis
Objectives It is important to find biomarkers associated with transition to illness in individuals
at clinical high-risk for psychosis (CHR). Here, we use free-water imaging, an advanced …

[HTML][HTML] Paradoxical increase of neurofilaments in SMA patients treated with onasemnogene abeparvovec-xioi

M Flotats-Bastardas, L Bitzan, C Grell… - Frontiers in …, 2023 - frontiersin.org
Background/Objective Neurofilament light chain (NfL) has been proposed as a biomarker
reflecting disease severity and therapy response in children with spinal muscular atrophy type …

[HTML][HTML] Paradoxical increase of neurofilaments in SMA patients treated with onasemnogene abeparvovec-xioi

M Flotats-Bastardas, L Bitzan, C Grell… - Frontiers in …, 2023 - frontiersin.org
Background/Objective Neurofilament light chain (NfL) has been proposed as a biomarker
reflecting disease severity and therapy response in children with spinal muscular atrophy type …

[PDF][PDF] Rational design of evolutionarily stable microbial kill switches

F Stirling, L Bitzan, S O'Keefe, E Redfield, JWK Oliver… - Mol Cell, 2018 - scholar.archive.org
The evolutionary stability of synthetic genetic circuits is key to both the understanding and
application of genetic control elements. One particularly useful but challenging situation is a …

Spectrum of mutations in the renin–angiotensin system genes in autosomal recessive renal tubular dysgenesis

…, M Bitzan, A Alfares, N Braverman, L Krogh… - Human …, 2012 - Wiley Online Library
Autosomal recessive renal tubular dysgenesis (RTD) is a severe disorder of renal tubular
development characterized by early onset and persistent fetal anuria leading to …

Elevated serum cobalt with metal-on-metal articulating surfaces

W Brodner, P Bitzan, V Meisinger… - The Journal of Bone …, 1997 - boneandjoint.org.uk
… are extremely variable, between 0 μg/l and 146 μg/l using atomic absorption spectrophotometry
and between 0.108 μg/l and 12.2 μg/l using neutron activation analysis. Contamination …

Acute renal failure in cystic fibrosis: association with inhaled tobramycin therapy

…, MS Schechter, SK Nagaraj, MM Bitzan - Pediatric …, 2002 - Wiley Online Library
… One of their 10 patients had peak tobramycin levels >20 mg/L. The serum creatinine of 792
μmol/L (9 mg/dL) at time of admission in our patient suggests that the insult to the kidneys …

Serum cobalt levels after metal-on-metal total hip arthroplasty

W Brodner, P Bitzan, V Meisinger, A Kaider… - JBJS, 2003 - journals.lww.com
… cobalt concentration was 1 μg/L at one year after surgery and 0.7 μg/L at five years. The …
μg/L in our laboratory. All concentrations below that limit were defined as 0.15 μg/L to allow …

Shiga Toxin-Producing Escherichia coli Infection and Antibodies against Stx2 and Stx1 in Household Contacts of Children with Enteropathic Hemolytic-Uremic …

K Ludwig, V Sarkim, M Bitzan, MA Karmali… - Journal of clinical …, 2002 - Am Soc Microbiol
… ), and 3 and 2%, respectively, had both anti-Stx2 and anti-Stx1 IgG (H + L). The … (H + L),
compared to 71% of Stx2-associated HUS cases. In individuals showing anti-Stx2 IgG (H + L), …