User profiles for L. Alderwick
Luke AlderwickLecturer in Molecular Microbiology, University of Birmingham Verified email at bham.ac.uk Cited by 3195 |
The mycobacterial cell wall—peptidoglycan and arabinogalactan
LJ Alderwick, J Harrison… - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
The mycobacterial bacillus is encompassed by a remarkably elaborate cell wall structure.
The mycolyl-arabinogalactan-peptidoglycan (mAGP) complex is essential for the viability of …
The mycolyl-arabinogalactan-peptidoglycan (mAGP) complex is essential for the viability of …
Structure, function and biosynthesis of the Mycobacterium tuberculosis cell wall: arabinogalactan and lipoarabinomannan assembly with a view to discovering new …
LJ Alderwick, HL Birch, AK Mishra… - Biochemical Society …, 2007 - portlandpress.com
In spite of effective antibiotics to treat TB (tuberculosis) since the early 1960s, we enter the
new millennium with TB, currently the leading cause of death from a single infectious agent, …
new millennium with TB, currently the leading cause of death from a single infectious agent, …
Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors
…, PA Lund, L Eggeling, LJ Alderwick… - Proceedings of the …, 2012 - National Acad Sciences
Resistance against currently used antitubercular therapeutics increasingly undermines
efforts to contain the worldwide tuberculosis (TB) epidemic. Recently, benzothiazinone (BTZ) …
efforts to contain the worldwide tuberculosis (TB) epidemic. Recently, benzothiazinone (BTZ) …
[HTML][HTML] Identification of a novel arabinofuranosyltransferase (AftA) involved in cell wall arabinan biosynthesis in Mycobacterium tuberculosis
LJ Alderwick, M Seidel, H Sahm, GS Besra… - Journal of Biological …, 2006 - ASBMB
The cell wall mycolyl-arabinogalactan-peptidoglycan complex is essential in mycobacterial
species, such as Mycobacterium tuberculosis, and is the target of several anti-tubercular …
species, such as Mycobacterium tuberculosis, and is the target of several anti-tubercular …
Pathophysiological implications of cell envelope structure in Mycobacterium tuberculosis and related taxa
…, M Ridell, M Watanabe, L Alderwick… - Tuberculosis …, 2015 - books.google.com
Members of the Mycobacterium tuberculosis complex are successful pathogens due in a
large part to the complex interactions of an array of very special lipid molecular classes and …
large part to the complex interactions of an array of very special lipid molecular classes and …
[HTML][HTML] Deletion of Cg-emb in corynebacterianeae leads to a novel truncated cell wall arabinogalactan, whereas inactivation of Cg-ubiA results in an arabinan …
LJ Alderwick, E Radmacher, M Seidel, R Gande… - Journal of Biological …, 2005 - ASBMB
The cell wall of Mycobacterium tuberculosis has a complex ultrastructure that consists of
mycolic acids connected to peptidoglycan via arabinogalactan (AG) and abbreviated as the …
mycolic acids connected to peptidoglycan via arabinogalactan (AG) and abbreviated as the …
[HTML][HTML] Identification of a novel arabinofuranosyltransferase AftB involved in a terminal step of cell wall arabinan biosynthesis in Corynebacterianeae, such as …
…, LJ Alderwick, HL Birch, H Sahm, L Eggeling… - Journal of biological …, 2007 - ASBMB
Arabinofuranosyltransferase enzymes, such as EmbA, EmbB, and AftA, play pivotal roles in
the biosynthesis of arabinogalactan, and the anti-tuberculosis agent ethambutol (EMB) …
the biosynthesis of arabinogalactan, and the anti-tuberculosis agent ethambutol (EMB) …
Biosynthesis of mycobacterial arabinogalactan: identification of a novel α (1→ 3) arabinofuranosyltransferase
HL Birch, LJ Alderwick, A Bhatt… - Molecular …, 2008 - Wiley Online Library
The cell wall mycolyl‐arabinogalactan–peptidoglycan complex is essential in mycobacterial
species, such as Mycobacterium tuberculosis and is the target of several antitubercular …
species, such as Mycobacterium tuberculosis and is the target of several antitubercular …
Two functional FAS-I type fatty acid synthases in Corynebacterium glutamicum
E Radmacher, LJ Alderwick, GS Besra… - …, 2005 - microbiologyresearch.org
… However, in a fasA background, the fasB mutation results in a slightly reduced growth yield,
l-glutamate production is increased, and comparative lipid analysis suggests that in vivo FAS…
l-glutamate production is increased, and comparative lipid analysis suggests that in vivo FAS…
Ethambutol, a cell wall inhibitor of Mycobacterium tuberculosis, elicits l-glutamate efflux of Corynebacterium glutamicum
…, KC Stansen, GS Besra, LJ Alderwick… - …, 2005 - microbiologyresearch.org
Corynebacterium glutamicum is used for the large-scale production of l-glutamate, but the
efflux of this amino acid is poorly understood. This study shows that addition of ethambutol (…
efflux of this amino acid is poorly understood. This study shows that addition of ethambutol (…