User profiles for L. Alderwick

Luke Alderwick

Lecturer in Molecular Microbiology, University of Birmingham
Verified email at bham.ac.uk
Cited by 3195

The mycobacterial cell wall—peptidoglycan and arabinogalactan

LJ Alderwick, J Harrison… - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
The mycobacterial bacillus is encompassed by a remarkably elaborate cell wall structure.
The mycolyl-arabinogalactan-peptidoglycan (mAGP) complex is essential for the viability of …

Structure, function and biosynthesis of the Mycobacterium tuberculosis cell wall: arabinogalactan and lipoarabinomannan assembly with a view to discovering new …

LJ Alderwick, HL Birch, AK Mishra… - Biochemical Society …, 2007 - portlandpress.com
In spite of effective antibiotics to treat TB (tuberculosis) since the early 1960s, we enter the
new millennium with TB, currently the leading cause of death from a single infectious agent, …

Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors

…, PA Lund, L Eggeling, LJ Alderwick… - Proceedings of the …, 2012 - National Acad Sciences
Resistance against currently used antitubercular therapeutics increasingly undermines
efforts to contain the worldwide tuberculosis (TB) epidemic. Recently, benzothiazinone (BTZ) …

[HTML][HTML] Identification of a novel arabinofuranosyltransferase (AftA) involved in cell wall arabinan biosynthesis in Mycobacterium tuberculosis

LJ Alderwick, M Seidel, H Sahm, GS Besra… - Journal of Biological …, 2006 - ASBMB
The cell wall mycolyl-arabinogalactan-peptidoglycan complex is essential in mycobacterial
species, such as Mycobacterium tuberculosis, and is the target of several anti-tubercular …

Pathophysiological implications of cell envelope structure in Mycobacterium tuberculosis and related taxa

…, M Ridell, M Watanabe, L Alderwick… - Tuberculosis …, 2015 - books.google.com
Members of the Mycobacterium tuberculosis complex are successful pathogens due in a
large part to the complex interactions of an array of very special lipid molecular classes and …

[HTML][HTML] Deletion of Cg-emb in corynebacterianeae leads to a novel truncated cell wall arabinogalactan, whereas inactivation of Cg-ubiA results in an arabinan …

LJ Alderwick, E Radmacher, M Seidel, R Gande… - Journal of Biological …, 2005 - ASBMB
The cell wall of Mycobacterium tuberculosis has a complex ultrastructure that consists of
mycolic acids connected to peptidoglycan via arabinogalactan (AG) and abbreviated as the …

[HTML][HTML] Identification of a novel arabinofuranosyltransferase AftB involved in a terminal step of cell wall arabinan biosynthesis in Corynebacterianeae, such as …

…, LJ Alderwick, HL Birch, H Sahm, L Eggeling… - Journal of biological …, 2007 - ASBMB
Arabinofuranosyltransferase enzymes, such as EmbA, EmbB, and AftA, play pivotal roles in
the biosynthesis of arabinogalactan, and the anti-tuberculosis agent ethambutol (EMB) …

Biosynthesis of mycobacterial arabinogalactan: identification of a novel α (1→ 3) arabinofuranosyltransferase

HL Birch, LJ Alderwick, A Bhatt… - Molecular …, 2008 - Wiley Online Library
The cell wall mycolyl‐arabinogalactan–peptidoglycan complex is essential in mycobacterial
species, such as Mycobacterium tuberculosis and is the target of several antitubercular …

Two functional FAS-I type fatty acid synthases in Corynebacterium glutamicum

E Radmacher, LJ Alderwick, GS Besra… - …, 2005 - microbiologyresearch.org
… However, in a fasA background, the fasB mutation results in a slightly reduced growth yield,
l-glutamate production is increased, and comparative lipid analysis suggests that in vivo FAS…

Ethambutol, a cell wall inhibitor of Mycobacterium tuberculosis, elicits l-glutamate efflux of Corynebacterium glutamicum

…, KC Stansen, GS Besra, LJ Alderwick… - …, 2005 - microbiologyresearch.org
Corynebacterium glutamicum is used for the large-scale production of l-glutamate, but the
efflux of this amino acid is poorly understood. This study shows that addition of ethambutol (…