Recent advances in optogenetics have improved the precision with which defined circuit
elements can be controlled optically in freely moving mammals; in particular, recombinase-…

Advances in optical manipulation and observation of neural activity have set the stage for
widespread implementation of closed-loop and activity-guided optical control of neural circuit …

… ), a fast, whole-brain regression and classification method developed for spatially and
temporally correlated data that automatically yields interpretable coefficient maps (Grosenick et al., …

Precisely defining the roles of specific cell types is an intriguing frontier in the study of intact
biological systems and has stimulated the rapid development of genetically encoded tools …

Social interaction is a complex behavior essential for many species and is impaired in major
neuropsychiatric disorders. Pharmacological studies have implicated certain …

INTRODUCTION Depression is an episodic form of mental illness, yet the circuit-level mechanisms
driving the induction, remission, and recurrence of depressive episodes over time are …

Anxiety—a sustained state of heightened apprehension in the absence of immediate threat—becomes
severely debilitating in disease states 1 . Anxiety disorders represent the most …

… The fact that T is null entails that Lm,λ is a rank deficient matrix. This in turn implies that the …
), we obtain from (8) that Lm,λ is also rank N − 1. Therefore Lm,λ and Y are both rank deficient. …

INTRODUCTION The drive to seek and experience reward is conserved across species and,
in mammals, involves interactions between subcortical dopaminergic systems and limbic …

Prolonged behavioral challenges can cause animals to switch from active to passive coping
strategies to manage effort-expenditure during stress; such normally adaptive behavioral …