Gene expression elucidates functional impact of polygenic risk for schizophrenia
Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants
confer liability is uncertain. The CommonMind Consortium sequenced RNA from dorsolateral …
confer liability is uncertain. The CommonMind Consortium sequenced RNA from dorsolateral …
[PDF][PDF] Landscape of conditional eQTL in dorsolateral prefrontal cortex and co-localization with schizophrenia GWAS
…, R Visintainer, LA Shinobu, PF Sullivan, LL Klei - The American Journal of …, 2018 - cell.com
Causal genes and variants within genome-wide association study (GWAS) loci can be
identified by integrating GWAS statistics with expression quantitative trait loci (eQTL) and …
identified by integrating GWAS statistics with expression quantitative trait loci (eQTL) and …
[PDF][PDF] Large-scale identification of common trait and disease variants affecting gene expression
…, JS Johnson, DM Ruderfer, HR Shah, LL Klei… - The American Journal of …, 2017 - cell.com
Genome-wide association studies (GWASs) have identified a multitude of genetic loci involved
with traits and diseases. However, it is often unclear which genes are affected in such loci …
with traits and diseases. However, it is often unclear which genes are affected in such loci …
[HTML][HTML] Transcriptome alterations are enriched for synapse-associated genes in the striatum of subjects with obsessive-compulsive disorder
SC Piantadosi, LL McClain, L Klei, J Wang… - Translational …, 2021 - nature.com
Obsessive-compulsive disorder (OCD) is a chronic and severe psychiatric disorder for which
effective treatment options are limited. Structural and functional neuroimaging studies have …
effective treatment options are limited. Structural and functional neuroimaging studies have …
[HTML][HTML] How rare and common risk variation jointly affect liability for autism spectrum disorder
L Klei, LL McClain, B Mahjani, K Panayidou… - Molecular autism, 2021 - Springer
Background Genetic studies have implicated rare and common variations in liability for
autism spectrum disorder (ASD). Of the discovered risk variants, those rare in the population …
autism spectrum disorder (ASD). Of the discovered risk variants, those rare in the population …
[HTML][HTML] Systematic review and consensus definitions for the Standardized Endpoints in Perioperative Medicine (StEP) initiative: cardiovascular outcomes
…, N Stevenson, JDJ Cooper, W van Klei… - British journal of …, 2021 - Elsevier
Background Adverse cardiovascular events are a leading cause of perioperative morbidity
and mortality. The definitions of perioperative cardiovascular adverse events are …
and mortality. The definitions of perioperative cardiovascular adverse events are …
An X-linked mitochondrial disease affecting cardiac muscle, skeletal muscle and neutrophil leucocytes
…, JA Berden, JM Van der Klei-Van Moorsel… - Journal of the …, 1983 - Elsevier
… 1-I died at the age of 61 yr, ll-2 at 75 yr. The others: II-l. Ill-7, Ill-12, Ill-19, IV-20, IV-21 and
IV-22 are alive and have no signs of cardiac disease, muscle weakness or proneness to …
IV-22 are alive and have no signs of cardiac disease, muscle weakness or proneness to …
[HTML][HTML] Schizophrenia-associated differential DNA methylation in brain is distributed across the genome and annotated to MAD1L1, a locus at which DNA …
…, LL McClain, CM Hensler, Y Wei, L Klei… - Translational …, 2022 - nature.com
DNA methylation (DNAm), the addition of a methyl group to a cytosine in DNA, plays an
important role in the regulation of gene expression. Single-nucleotide polymorphisms (SNPs) …
important role in the regulation of gene expression. Single-nucleotide polymorphisms (SNPs) …
Destruction of aromatic pollutants by UV light catalyzed oxidation with hydrogen peroxide
DW Sundstrom, BA Weir, HE Klei - Environmental progress, 1989 - Wiley Online Library
… The experiments were conducted in a recirculating flow reactor system, which has been
previously described [ll]. The annular reactor consisted of two 20 cm quartz tubes with inner and …
previously described [ll]. The annular reactor consisted of two 20 cm quartz tubes with inner and …
Genetic and environmental parameters associated with linearized type appraisal scores
L Klei, EJ Pollak, RL Quaas - Journal of dairy science, 1988 - Elsevier
Linearized type records on 14,525 Holstein cows were analyzed to obtain genetic and
environmental parameters. Each record consisted of scores on 15 linear type traits recorded on …
environmental parameters. Each record consisted of scores on 15 linear type traits recorded on …