Alzheimer’s disease (AD) is highly heritable and recent studies have identified over 20
disease-associated genomic loci. Yet these only explain a small proportion of the genetic …

Late-onset Alzheimer’s disease is a prevalent age-related polygenic disease that accounts
for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying …

Autism spectrum disorders (ASDs) are childhood neurodevelopmental disorders with complex
genetic origins 1 , 2 , 3 , 4 . Previous studies focusing on candidate genes or genomic …

Problematic alcohol use (PAU) is a leading cause of death and disability worldwide. Although
genome-wide association studies have identified PAU risk genes, the genetic architecture …

Cannabis use is a heritable trait that has been associated with adverse mental health outcomes.
In the largest genome-wide association study (GWAS) for lifetime cannabis use to date (…

The direct estimation of heritability from genome-wide common variant data as implemented
in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to …

Nearly all human complex traits and disease phenotypes exhibit some degree of sex differences,
including differences in prevalence, age of onset, severity or disease progression. Until …

Objective: Tourette’s syndrome is polygenic and highly heritable. Genome-wide association
study (GWAS) approaches are useful for interrogating the genetic architecture and …

We report identification of a novel genetic locus ( GLC1P ) for normal tension glaucoma (NTG)
on chromosome 12q14 using linkage studies of an African-American pedigree (maximum …

Tourette's syndrome (TS) is a developmental disorder that has one of the highest familial
recurrence rates among neuropsychiatric diseases with complex inheritance. However, the …