User profiles for L. J. Coin
Lachlan CoinPeter Doherty Institute for Infection and Immunity and University of Melbourne Centre for … Verified email at unimelb.edu.au Cited by 45975 |
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
Concentrations of liver enzymes in plasma are widely used as indicators of liver disease.
We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci …
We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci …
TreeFam: a curated database of phylogenetic trees of animal gene families
TreeFam is a database of phylogenetic trees of gene families found in animals. It aims to
develop a curated resource that presents the accurate evolutionary history of all animal gene …
develop a curated resource that presents the accurate evolutionary history of all animal gene …
[HTML][HTML] Diagnosis of childhood tuberculosis and host RNA expression in Africa
…, H Twahir, RJ Wilkinson, LJ Coin… - … England Journal of …, 2014 - Mass Medical Soc
Background Improved diagnostic tests for tuberculosis in children are needed. We hypothesized
that transcriptional signatures of host blood could be used to distinguish tuberculosis …
that transcriptional signatures of host blood could be used to distinguish tuberculosis …
[HTML][HTML] Detection of tuberculosis in HIV-infected and-uninfected African adults using whole blood RNA expression signatures: a case-control study
Background A major impediment to tuberculosis control in Africa is the difficulty in diagnosing
active tuberculosis (TB), particularly in the context of HIV infection. We hypothesized that a …
active tuberculosis (TB), particularly in the context of HIV infection. We hypothesized that a …
Transcriptomic studies of malaria: a paradigm for investigation of systemic host-pathogen interactions
Transcriptomics, the analysis of genome-wide RNA expression, is a common approach to
investigate host and pathogen processes in infectious diseases. Technical and bioinformatic …
investigate host and pathogen processes in infectious diseases. Technical and bioinformatic …
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption
Alcohol consumption is a moderately heritable trait, but the genetic basis in humans is
largely unknown, despite its clinical and societal importance. We report a genome-wide …
largely unknown, despite its clinical and societal importance. We report a genome-wide …
A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order
BACKGROUND: Hay fever or seasonal allergic rhinitis (AR) is a chronic disorder associated
with IgE sensitization to grass. The underlying genetic variants have not been studied …
with IgE sensitization to grass. The underlying genetic variants have not been studied …
Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria
The pathogenesis of infectious diseases depends on the interaction of host and pathogen.
In Plasmodium falciparum malaria, host and parasite processes can be assessed by dual …
In Plasmodium falciparum malaria, host and parasite processes can be assessed by dual …
[HTML][HTML] Mycobacterium tuberculosis Exploits a Molecular Off Switch of the Immune System for Intracellular Survival
Mycobacterium tuberculosis (M. tuberculosis) survives and multiplies inside human macrophages
by subversion of immune mechanisms. Although these immune evasion strategies are …
by subversion of immune mechanisms. Although these immune evasion strategies are …
[HTML][HTML] Identification of reduced host transcriptomic signatures for tuberculosis disease and digital PCR-based validation and quantification
Recently, host whole blood gene expression signatures have been identified for diagnosis
of tuberculosis (TB). Absolute quantification of the concentrations of signature transcripts in …
of tuberculosis (TB). Absolute quantification of the concentrations of signature transcripts in …