OBJECTIVE: Increasing evidence points to a strong genetic component to osteoarthritis (OA)
and that certain changes that occur in osteoarthritic cartilage recapitulate the …

Joint morphogenesis requires mechanical activity during development. Loss of mechanical
strain causes abnormal joint development, which can impact long-term joint health. Although …

Abnormal joint morphogenesis is linked to clinical conditions such as Developmental
Dysplasia of the Hip (DDH) and to osteoarthritis (OA). Muscle activity is known to be important …

Objective There is increasing evidence that joint shape is a potent predictor of osteoarthritis (OA)
risk; yet the cellular events underpinning joint morphogenesis remain unclear. We …

Skeletal morphogenesis occurs through tightly regulated cell behaviors during development;
many cell types alter their behavior in response to mechanical strain. Skeletal joints are …

Developmental dysplasia of the hip (DDH), a malformation of the acetabulum, is a frequent
cause of early onset osteoarthritis. The disease encompasses a spectrum of severities, some …

Purpose: The purpose of our work is to ascertain the extent to which zebrafish can be used
as an animal model to dissect how osteoarthritis susceptibility genes affect cell behaviour in …

… Skin blood flow in response to LH has been shown to be increased during the mid-luteal …
the LH and RH tests. We hypothesized that estradiol would increase the response to both LH …

… LH)-1] compared with their prepubescent counterparts. Conclusion: These findings suggest
that developmental changes influence knee mechanics during landings in female athletes …

Previous experiments in mice showed that dietary trans-fats could play a role in non-alcoholic
steatohepatitis (NASH) yet little is known about the accumulation trans-fats in hepatic lipid …