INTRODUCTION To date, 559 humans have been flown into space, but long-duration (>300
days) missions are rare (n = 8 total). Long-duration missions that will take humans to Mars …

Gene co-expression networks capture biologically important patterns in gene expression
data, enabling functional analyses of genes, discovery of biomarkers, and interpretation of …

Epigenetic modifications confer stable transcriptional patterns in the brain, and both normal
and abnormal brain function involve specialized brain regions. We examined DNA …

Cell type-specific transcriptional differences between brain tissues from donors with Alzheimer's
disease (AD) and unaffected controls have been well documented, but few studies have …

The impact of inherited genetic variation on gene expression in humans is well-established.
The majority of known expression quantitative trait loci (eQTLs) impact expression of local …

The cell cycle ensures genome maintenance by coordinating the processes of DNA replication
and chromosome segregation. Of particular importance is the irreversible transition from …

… To make a more precise comparison, we examined the correlation between the methylation
differences between two tissues as measured separately in Rizzardi et al. [12] and this study …

DNA replication is a highly regulated process that is initiated from replication origins, but the
elements of chromatin structure that contribute to origin activity have not been fully …

Replication-coupled destruction of a cohort of cell cycle proteins ensures efficient and
precise genome duplication. Three proteins destroyed during replication via the CRL4 CDT2 …

Tauopathies are a group of neurodegenerative diseases defined by abnormal aggregates of
tau, a microtubule-associated protein encoded by MAPT. MAPT expression is near absent …