The gastrointestinal (GI) tract epithelium is continuously replenished by actively cycling stem
and progenitor cells. These cell compartments are regulated to balance proliferation and …

The definition, regulation and function of intestinal stem cells (ISCs) has been hotly debated.
Recent discoveries have started to clarify the nature of ISCs, but many questions remain. …

Notch signaling is known to regulate the proliferation and differentiation of intestinal stem and
progenitor cells; however, direct cellular targets and specific functions of Notch signals had …

Adenosine is a determinant of metabolic control of organ function increasing oxygen supply
through the A2 class of adenosine receptors and reducing oxygen demand through A1 …

The human salivary amylase genes are associated with two inserted elements, a gamma-actin-processed
pseudogene and an endogenous retroviral-like element. To test the …

Organoid culture systems have emerged as a frontier technology in liver and biliary research.
These three‐dimensional (3D) cell cultures derived from pluripotent and adult …

… Linda C Samuelson: study concept and design; analysis and interpretation of data;
drafting of the manuscript; critical revision of the manuscript for important intellectual content; …

Graft-versus-host disease (GVHD) is the main complication of allogeneic bone marrow
transplantation. Current strategies to control GVHD rely on global immunosuppression. These …

Background & Aims: Epithelial stem cells in the stomach are responsible for constant renewal
of the epithelium through generation of multiple gastric cell lineages that populate the …

To further understand the role of the peptide hormone gastrin in the development and function
of the stomach, we have generated gastrin-deficient mice by gene targeting in embryonic …