Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the
development of innate and adaptive immune responses. Canonical type I IFN signalling …

TNF is a pleiotropic cytokine with important functions in homeostasis and disease
pathogenesis. Recent discoveries have provided insights into TNF biology that introduce new …

Interferon-γ (IFN-γ) is an important mediator of immunity and inflammation that utilizes the
JAK-STAT signaling pathway to activate the STAT1 transcription factor. Many functions of IFN-γ …

Description of macrophage activation is currently contentious and confusing. Like the biblical
Tower of Babel, macrophage activation encompasses a panoply of descriptors used in …

IFNγ is a cytokine with important roles in tissue homeostasis, immune and inflammatory
responses and tumour immunosurveillance. Signalling by the IFNγ receptor activates the Janus …

CD4 + T cells are central mediators of autoimmune pathology; however, defining their key
effector functions in specific autoimmune diseases remains challenging. Pathogenic CD4 + T …

The control of IL-10 production and mechanisms that mediate synergy between IFN-γ and
TLR ligands are not well understood. We report that IFN-γ augments induction of TNFα by TLR …

Rapid induction of inflammatory genes by tumor necrosis factor (TNF) has been well studied,
but little is known about delayed and chronic TNF responses. Here we investigated the …

Emerging concepts suggest that the functional phenotype of macrophages is regulated by
transcription factors that define alternative activation states. We found that RBP-J, the main …

Fibroblasts regulate tissue homeostasis, coordinate inflammatory responses, and mediate
tissue damage. In rheumatoid arthritis (RA), synovial fibroblasts maintain chronic inflammation …