The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its
associated disease, COVID-19, has demonstrated the devastating impact of a novel, …

Immune memory is a defining feature of the acquired immune system, but activation of the
innate immune system can also result in enhanced responsiveness to subsequent triggers. …

Celiac disease (CD) is a gluten-sensitive enteropathy that develops in genetically susceptible
individuals by exposure to cereal gluten proteins. This review integrates insights from …

The dogma that adaptive immunity is the only arm of the immune response with memory
capacity has been recently challenged by several studies demonstrating evidence for memory-…

The considerable range of observed phenotypic variation in human populations may reflect,
in part, distinctive processes of natural selection and adaptation to variable environmental …

The similarities and differences between trained immunity and other immune processes are
the subject of intense interrogation. Therefore, a consensus on the definition of trained …

Pathogens have always been a major cause of human mortality, so they impose strong
selective pressure on the human genome. Data from population genetic studies, including …

… We thank all members of the Barreiro laboratory and the Poinar laboratory for their constructive
comments and feedback. We thank J. Tung for her comments and edits to the manuscript. …

10.7554/eLife.05224.001 Social relationships have profound effects on health in humans and
other primates, but the mechanisms that explain this relationship are not well understood. …

Individuals from different populations vary considerably in their susceptibility to immune-related
diseases. To understand how genetic variation and natural selection contribute to these …