Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants
confer liability is uncertain. The CommonMind Consortium sequenced RNA from dorsolateral …

Some cases of autosomal dominant familial amyotrophic lateral sclerosis (FALS) are associated
with mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1), suggesting …

Mounting evidence suggests that defects in energy metabolism contribute to the pathogenesis
of Alzheimer disease (AD). Cytochrome c oxidase (CO) is kinetically abnormal, and its …

Mutations in copper/zinc superoxide dismutase (SOD1) cause a subset of cases of autosomal
dominant familial amyotrophic lateral sclerosis (FALS). Transgenic mice that express …

Causal genes and variants within genome-wide association study (GWAS) loci can be
identified by integrating GWAS statistics with expression quantitative trait loci (eQTL) and …

The sodium and ammonium salts of N‐methyl‐D‐glucamine dithiocarbamate were prepared
and their usefulness as antidotes for cadmium intoxication investigated. This chelating …

Mutations in copper/zinc superoxide dismutase (SOD1) account for 10–20% of a familial
form of amyotrophic lateral sclerosis (ALS). A common feature of SOD1 mutants is abnormal …

Mitochondrial DNA (mtDNA) mutations cause a variety of mitochondrial disorders for which
effective treatments are lacking. Emerging data indicate that selective mitochondrial …

Object. Pallidotomy for the treatment of medically refractory Parkinson's disease (PD) has
enjoyed renewed popularity. However, the optimal surgical technique, lesion location, and long…

Object. The surgical treatment of Parkinson disease (PD) has undergone a dramatic shift, from
stereotactic ablative procedures toward deep brain stimulaion (DBS). The authors studied …