How DNA is organized in three dimensions inside the cell nucleus and how this affects the
ways in which cells access, read and interpret genetic information are among the longest …

The 4D Nucleome Network aims to develop and apply approaches to map the structure and
dynamics of the human and mouse genomes in space and time with the goal of gaining …

Coordinated regulation of gene expression relies on transcription factors (TFs) binding to
specific DNA sites. Our large-scale information–theoretical analysis of >950 TF-binding motifs …

We describe Hi-C, a method that probes the three-dimensional architecture of whole genomes
by coupling proximity-based ligation with massively parallel sequencing. We constructed …

Proteins, nucleic acids, and small molecules form a dense network of molecular interactions
in a cell. Molecules are nodes of this network, and the interactions between them are edges. …

Topologically associating domains (TADs) are fundamental structural and functional building
blocks of human interphase chromosomes, yet the mechanisms of TAD formation remain …

The molecular mechanisms underlying folding of mammalian chromosomes remain poorly
understood. The transcription factor CTCF is a candidate regulator of chromosomal structure. …

Extracting biologically meaningful information from chromosomal interactions obtained with
genome-wide chromosome conformation capture (3C) analyses requires the elimination of …

We present HiGlass, an open source visualization tool built on web technologies that
provides a rich interface for rapid, multiplex, and multiscale navigation of 2D genomic maps …

Mitotic chromosomes are among the most recognizable structures in the cell, yet for over a
century their internal organization remains largely unsolved. We applied chromosome …